ArticleNeuroscience letters2015
Examining the association between Apolipoprotein E (APOE) and self-reported sleep disturbances in non-demented older adults.
Article in Neuroscience letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Physical Activity Moderates the Relationship between Cardiovascular Disease Risk Burden and Cognition in Older Adults.Neuroepidemiology · 2025Article
- Snoring and risk of dementia: a prospective cohort and Mendelian randomization study.medRxiv : the preprint server for health sciences · 2023Article
- Article
- Evidence for a contribution of the APOE (but not the ACE) gene to the sleep profile of non-demented elderly adults.International journal of molecular epidemiology and genetics · 2019Article
- Effects of Six-Month Aerobic Exercise Intervention on Sleep in Healthy Older Adults in theJournal of Alzheimer's disease reports · 2018Article
- The Relationship Between Apolipoprotein ε4 Carrier Status and Sleep Characteristics in Cognitively Normal Older Adults.Journal of geriatric psychiatry and neurology · 2017Article
- Article
- Data from a cross-sectional study on Apolipoprotein E (APOE-ε4) and snoring/sleep apnea in non-demented older adults.Data in brief · 2015Article
- Sleep and the aging brain. A multifaceted approach.Sleep science (Sao Paulo, Brazil)Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
We aimed to examine the association between Apolipoprotein E (APOE) and sleep disturbances. This is a cross-sectional study, from the Washington Heights-Inwood Community Aging Project (WHICAP). A total of 1944 non-demented older adults took part in the study. Sleep dysfunction was measured using sleep categories derived from the Medical Outcomes Study Sleep Scale. Genetic association between APOE-ϵ4 genotype and sleep disturbances was assessed using unadjusted linear regression models. Secondary analyses were conducted adjusting for age, sex, education, ethnicity and body mass index (BMI). In the unadjusted model, individuals carrying the APOE-ϵ4 allele showed lower levels of snoring (β=-0.02, SE=0.01, p=0.010) and sleep apnea (β=-0.01, SE=0.01, p=0.037) when compared to non-ϵ4 carriers. After covariates' adjustment, ϵ4 carriers demonstrated stronger association with lower levels of both snoring (β=-0.02, SE=0.01, p=0.006), and sleep apnea (β=-0.01, SE=0.01, p=0.018). Our results suggest that APOE-ϵ4 is associated with decreased problems in snoring and sleep apnea, in non-demented older adults.
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