ArticleNature communications2015
A novel thiol-reductase activity of Arabidopsis YUC6 confers drought tolerance independently of auxin biosynthesis.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 112 citations in OpenAlex.
- Coordination of drought-adaptive root growth plasticity through auxin homeostasis by the ZmSPL12-ZmYUC5 module in maize.The New phytologist · 2026Article
- The old nourishes the new: 100 years of leaf senescence studies in Plant Physiology.Plant physiology · 2026Review
- A genome-wide analysis of YUCCA genes in cotton and the functional study of GhYUC19 in plant development.BMC plant biology · 2026Article
- Unexpected Dual Function of Plant YUCCA Enzymes Links Chlorophyll Catabolism to Auxin Homeostasis.Angewandte Chemie (International ed. in English) · 2026Article
- Genome-Wide Analysis of thePlants (Basel, Switzerland) · 2026Article
- Bacillus endophyticus J13 imparts drought tolerance to Arabidopsis thaliana by regulating the plant auxin-dependent auxin conjugation pathway.Plant cell reports · 2025Article
- The auxin gatekeepers: Evolution and diversification of the YUCCA family.The Plant journal : for cell and molecular biology · 2025Article
- Association mapping unravels the genetic basis for drought related traits in different developmental stages of barley.Scientific reports · 2024Article
- A CAM-Related NF-YB Transcription Factor Enhances Multiple Abiotic Stress Tolerance inInternational journal of molecular sciences · 2024Article
- Utilizing transcriptomics and metabolomics to unravel key genes and metabolites of maize seedlings in response to drought stress.BMC plant biology · 2024Article
- Seed priming with ascorbic acid and spermidine regulated auxin biosynthesis to promote root growth of rice under drought stress.Frontiers in plant science · 2024Article
- HISTONE DEACETYLASE 6 interaction with ABSCISIC ACID-INSENSITIVE 5 decreases apple drought tolerance.Plant physiology · 2023Article
- Network Biology Analyses and Dynamic Modeling of Gene Regulatory Networks under Drought Stress Reveal Major Transcriptional Regulators inInternational journal of molecular sciences · 2023Article
- Novel flavin-containing monooxygenase protein FMO1 interacts with CAT2 to negatively regulate drought tolerance through ROS homeostasis and ABA signaling pathway in tomato.Horticulture research · 2023Article
- Genomic Survey of Flavin Monooxygenases in Wild and Cultivated Rice Provides Insight into Evolution and Functional Diversities.International journal of molecular sciences · 2023Article
- Genome-Wide Identification, Expression Analysis, and Potential Roles under Abiotic Stress of theInternational journal of molecular sciences · 2023Article
- Identification and evolution analysis ofFrontiers in plant science · 2023Article
- Allelic shift in cis-elements of the transcription factorScience advances · 2022Article
- Identification of the Regulators of Epidermis Development under Drought- and Salt-Stressed Conditions by Single-Cell RNA-Seq.International journal of molecular sciences · 2022Article
- Zinc-finger protein MdBBX7/MdCOL9, a target of MdMIEL1 E3 ligase, confers drought tolerance in apple.Plant physiology · 2022Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
YUCCA (YUC) proteins constitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesis. Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accumulation under drought and oxidative stresses. Co-overexpression of an IAA-conjugating enzyme reduces IAA levels but drought stress tolerance is unaffected, indicating that the stress-related phenotype is not based on IAA overproduction. YUC6 contains a previously unrecognized FAD- and NADPH-dependent thiol-reductase activity (TR) that overlaps with the FMO domain involved in IAA biosynthesis. Mutation of a conserved cysteine residue (Cys-85) preserves FMO but suppresses TR activity and stress tolerance, whereas mutating the FAD- and NADPH-binding sites, that are common to TR and FMO domains, abolishes all outputs. We provide a paradigm for a single protein playing a dual role, regulating plant development and conveying stress defence responses.
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