ArticleTranslational stroke research2015
Critical early thrombolytic and endovascular reperfusion therapy for acute ischemic stroke victims: a call for adjunct neuroprotection.
Article in Translational stroke research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Targeting DNA Damage and Repair Pathways in Cerebral Ischemic Stroke: From Bench to Bedside.Translational stroke research · 2026Review
- Effect of electroacupuncture on global cerebral ischemia-reperfusion injury in rats: A urine proteome analysis.Brain and behavior · 2024Article
- Delta Opioid Peptide Targets Brain Microvascular Endothelial Cells Reducing Apoptosis to Relieve Hypoxia-Ischemic/Reperfusion Injury.Pharmaceutics · 2022Article
- Effect of Pericytes on Cerebral Microvasculature at Different Time Points of Stroke.BioMed research international · 2021Review
- Imaging Acute Stroke: From One-Size-Fit-All to Biomarkers.Frontiers in neurology · 2021Review
- Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke.International journal of environmental research and public health · 2020Article
- Pericytes in Microvessels: From "Mural" Function to Brain and Retina Regeneration.International journal of molecular sciences · 2019Review
- Enhancing Base Excision Repair of Mitochondrial DNA to Reduce Ischemic Injury Following Reperfusion.Translational stroke research · 2019Article
- Effects of Therapeutic Hypothermia Combined with Other Neuroprotective Strategies on Ischemic Stroke: Review of Evidence.Aging and disease · 2018Review
- Translational Stroke Research Guideline Projections: The 20/20 Standards.Translational stroke research · 2018Article
- Data Standardization and Quality Management.Translational stroke research · 2018Article
- Mst1: Function and Mechanism in Brain and Myocardial Ischemia Reperfusion Injury.Current neuropharmacology · 2018Review
- Translational Stroke Research Opportunities and a Strategy to Develop Effective Cytoprotection.Translational stroke research · 2017Article
- The High Cost of Stroke and Stroke Cytoprotection Research.Translational stroke research · 2017Review
- Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NADStroke · 2017Article
- Cytoprotective Drug-Tissue Plasminogen Activator Protease Interaction Assays: Screening of Two Novel Cytoprotective Chromones.Translational stroke research · 2017Article
- Pericytes in Brain Injury and Repair After Ischemic Stroke.Translational stroke research · 2017Review
- Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?Translational stroke research · 2017Article
- Mechanisms, Imaging, and Therapy in Stroke Recovery.Translational stroke research · 2017Article
- Treatment of Cervical Artery Dissection: Antithrombotics, Thrombolysis, and Endovascular Therapy.BioMed research international · 2017Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Today, there is an enormous amount of excitement in the field of stroke victim care due to the recent success of MR. CLEAN, SWIFT PRIME, ESCAPE, EXTEND-IA, and REVASCAT endovascular trials. Successful intravenous (IV) recombinant tissue plasminogen activator (rt-PA) clinical trials [i.e., National Institute of Neurological Disorders and Stroke (NINDS) rt-PA trial, Third European Cooperative Acute Stroke Study (ECASSIII), and Third International Stroke study (IST-3)] also need to be emphasized. In the recent endovascular and thrombolytic trials, there is statistically significant improvement using both the National Institutes of Health Stroke Scale (NIHSS) and the modified Rankin Score (mRS) scale, but neither approach promotes complete recovery in patients enrolled within any particular NIHSS or mRS score tier. Absolute improvement (mRS 0-2 at 90 days) with endovascular therapy is 13.5-31 %, whereas thrombolytics alone also significantly improve patient functional independence, but to a lesser degree (NINDS rt-PA trial 13 %). This article has 3 main goals: (1) first to emphasize the utility and cost-effectiveness of rt-PA to treat stroke; (2) second to review the recent endovascular trials with respect to efficacy, safety, and cost-effectiveness as a stroke treatment; and (3) to further consider and evaluate strategies to develop novel neuroprotective drugs. A thesis will be put forth so that future stroke trials and therapy development can optimally promote recovery so that stroke victims can return to "normal" life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.