Evidence map›Paper›PMID 26314212›Full record

ArticleChemical communications (Cambridge, England)2015

Bulged Invader probes: activated duplexes for mixed-sequence dsDNA recognition with improved thermodynamic and kinetic profiles.

Dale C Guenther, Saswata Karmakar, Patrick J Hrdlicka

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Dale C GuentherDepartment of Chemistry, University of Idaho, 875 Perimeter Dr, Moscow, ID 83844-2343, USA. hrdlicka@uidaho.edu.
Saswata Karmakar
Patrick J Hrdlicka
University of Idaho · US

Funding

Women's health: interplay of maternal diet and key demographics on neurological health in the rural frontier and remote WestP20GM103408 · NIGMS · UNIVERSITY OF IDAHO · PI Carolyn Hovde Bohach · 2012 to 2026
$59.8M
Invader LNAs as Novel Gene Specific TherapeuticsR01GM088697 · NIGMS · UNIVERSITY OF IDAHO · PI HILL, RODNEY ALLAN, HRDLICKA, PATRICK J. · 2009 to 2011
$519k
HSRD VA PEC 13-001NIGMS NIH HHS GM088697NIGMS NIH HHS P20 GM103408NIGMS NIH HHS R01 GM088697
6 · The paper itself

Abstract

Double-stranded oligonucleotides with +1 interstrand zipper arrangements of intercalator-functionalized nucleotides are energetically activated for recognition of mixed-sequence double-stranded DNA. Incorporation of nonyl (C9) bulges at specific positions of these probes, results in more highly affine (>5-fold), faster (>4-fold) and more persistent dsDNA recognition relative to conventional Invader probes.

Indexed as

ThermodynamicsBase SequenceDNADNA ProbesKineticsMolecular StructureDNADNA Probes

Identifiers

PMID26314212
PMCPMC4589525
OpenAlexW1906122628

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.