Evidence map›Paper›PMID 26313939›Full record

ArticlePloS one2015

Immunologic Predictors of Liver Transplantation Outcomes in HIV-HCV Co-Infected Persons.

Ashwin Balagopal, Burc Barin, Jeffrey Quinn, Rodney Rogers, Mark S Sulkowski, Peter G Stock

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Ashwin BalagopalDepartment of Medicine, Johns Hopkins University, Baltimore, MD, 21205, United States of America.
Burc BarinThe EMMES Corporation, Rockville, MD, 20850, United States of America.
Jeffrey QuinnDepartment of Medicine, Johns Hopkins University, Baltimore, MD, 21205, United States of America.
Rodney RogersDepartment of Surgery, University of California San Francisco (UCSF), San Francisco, CA, 94122, United States of America.
Mark S SulkowskiDepartment of Medicine, Johns Hopkins University, Baltimore, MD, 21205, United States of America.
Peter G StockDepartment of Surgery, University of California San Francisco (UCSF), San Francisco, CA, 94122, United States of America.
Johns Hopkins University · USUniversity of California, San Francisco · USEmmes (United States) · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Holger Willenbring · 1986 to 2026
$30.7M
Solid Organ Transplantation in HIV: Multi-Site StudyU01AI052748 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STOCK, PETER G · 2003 to 2010
$25.9M
The Progression of Hepatitis C Among IDUs with HIVR01DA016078 · NIDA · JOHNS HOPKINS UNIVERSITY · PI BALAGOPAL, ASHWIN, THOMAS, DAVID L · 2002 to 2016
$10.9M
Patient Oriented Research in Hepatitis C-infected Injection Drug UsersK24DA034621 · NIDA · JOHNS HOPKINS UNIVERSITY · PI SULKOWSKI, MARK SEBASTIAN · 2012 to 2022
$1.2M
NIAID NIH HHS AI 052748NIAID NIH HHS AI 094189NIAID NIH HHS P30 AI094189NIAID NIH HHS U01 AI052748NIDA NIH HHS DA 016078NIDA NIH HHS DA 034621NIDA NIH HHS K24 DA034621NIDA NIH HHS R01 DA016078NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Liver disease is a leading cause of mortality among HIV-infected persons in the highly active anti-retroviral therapy (HAART) era. Hepatitis C Virus (HCV) co-infection is prevalent in, and worsened by HIV; consequently many co-infected persons require liver transplantation (LT). Despite the need, post-LT outcomes are poor in co-infection. We examined predictors of outcomes post-LT. Immunologic biomarkers of immune activation, microbial translocation, and Th1/Th2 skewing were measured pre-LT in participants enrolled in a cohort of HIV infected persons requiring solid organ transplant (HIVTR). Predictive biomarkers were analyzed in Cox-proportional hazards models; multivariate models included known predictors of outcome and biomarkers from univariate analyses. Sixty-nine HIV-HCV co-infected persons with available pre-LT samples were tested: median (IQR) CD4+ T-cell count was 286 (210-429) cells mm-3; 6 (9%) had detectable HIV RNA. Median (IQR) follow-up was 2.1 (0.7-4.0) years, 29 (42%) people died, 35 (51%) had graft loss, 22 (32%) were treated for acute rejection, and 14 (20%) had severe recurrent HCV. In multivariate models, sCD14 levels were significantly lower in persons with graft loss post-LT (HR 0.10 [95%CI 0.02-0.68]). IL-10 levels were higher in persons with rejection (HR 2.10 [95%CI 1.01-4.34]). No markers predicted severe recurrent HCV. Monocyte activation pre-LT may be mechanistically linked to graft health in HIV-HCV co-infection.

Indexed as

Liver TransplantationPostoperative ComplicationsAdultBiomarkersCoinfectionFemaleGraft RejectionGraft SurvivalHepacivirusHepatitis C, ChronicHIV-1HIV InfectionsHumansMaleMiddle AgedRisk FactorsBiomarkers

Identifiers

PMID26313939
PMCPMC4551738
OpenAlexW2123677637

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.