ArticleMedicine2015
Immediate Postoperative Low Platelet Counts After Living Donor Liver Transplantation Predict Early Allograft Dysfunction.
Article in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 44 citations in OpenAlex.
- The Mechanisms behind Thrombocytopenia in Patients with Portal Hypertension and Chronic Liver Disease.Journal of clinical and translational hepatology · 2025Review
- Spleen volume after stage-I associated liver partition and portal vein ligation for staged hepatectomy predicts future liver remnant.Langenbeck's archives of surgery · 2025Article
- Dualistic role of platelets in living donor liver transplantation: Are they harmful?World journal of gastroenterology · 2022Review
- Using Rotational Thromboelastometry to Identify Early Allograft Dysfunction after Living Donor Liver Transplantation.Journal of clinical medicine · 2021Article
- Uric Acid as a Predictor for Early Allograft Dysfunction after Living Donor Liver Transplantation: A Prospective Observational Study.Journal of clinical medicine · 2021Article
- A nomogram for prediction of early allograft dysfunction in living donor liver transplantation.Medicine · 2020Article
- Platelet and liver regeneration after liver surgery.Surgery today · 2020Review
- The postoperative hepatic artery resistance index after living donor liver transplantation can predict early allograft dysfunction.Medicine · 2020Observational
- Clinical Implications of Thrombocytopenia for the Cirrhotic Patient.Hepatic medicine : evidence and research · 2020Review
- Low platelet count: Predictor of death and graft loss after liver transplantation.World journal of hepatology · 2019Article
- Rotational thromboelastometry (ROTEM) 24 hours post liver transplantation predicts early allograft dysfunction.Romanian journal of anaesthesia and intensive care · 2018Article
- Assessing Influences of Perioperative Transfusion on Early- and Late-Term Outcomes after Living Donor Liver Transplantation: Methodological Issues.Chinese medical journal · 2018Article
- Thrombocytopenia after liver transplantation: Should we care?World journal of gastroenterology · 2018Review
- The impact of serum cytokines in the development of early allograft dysfunction in living donor liver transplantation.Medicine · 2018Observational
- Platelets as Modulators of Liver Diseases.Seminars in thrombosis and hemostasis · 2018Review
- Fibrosis-4 Model Influences Results of Patients with Hepatocellular Carcinoma Undergoing Hepatectomy.BioMed research international · 2018Article
- Evolution of platelet functions in cirrhotic patients undergoing liver transplantation: A prospective exploration over a month.PloS one · 2018Article
- Association of interleukin-28B polymorphisms with platelet count and liver function recovery after liver transplant.Medicine · 2017Article
- Splenectomy before adult liver transplantation: a retrospective study.BMC surgery · 2017Article
- Liver transplantation versus surgical resection for HCC meeting the Milan criteria: A propensity score analysis.Medicine · 2016Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate whether the platelets can improve liver function by mediating liver regeneration. Using a retrospective cohort with 234 consecutive adult-to-adult living donor liver transplantation recipients, we have discussed the relationship between immediate postoperative platelet count and outcome. Patients have been stratified into Low Platelet Group (106 patients) with platelet ≤68 × 10/L and High Platelet Group (128 patients) with platelet >68 × 10/L.Low Platelet Group has a higher rate of preoperative thrombocytopenia (90.6% vs. 32.8%, P<0.001), higher model for end-stage liver disease score (15 vs. 11, P<0.001), cirrhosis (86.8% vs. 76.6%, P=0.046), hepatorenal syndrome (18.2% vs. 4.0%, P=0.005) and fulminant hepatic failure (26.4% vs. 7.8%, P<0.001). The packed red blood cells transfusion (7.5 vs. 5, P = 0.023) and plasma transfusion (1275 mL vs. 800 mL, P=0.001) are more in patients with low platelet count. Low Platelet Group has a higher early allograft dysfunction (EAD) (22.6% vs. 7.0%, P=0.001) and severe complications (22.6% vs. 10.9%, P = 0.016). The 90-day mortality between the 2 groups is similar. The multivariate analysis has found that postoperative platelet ≤68 × 10/L is an independent risk factor for EAD.Platelet maybe influences the functional status of the liver by promoting graft regeneration after liver transplantation.
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