ArticlePloS one2015
Genetic Adaptation of Achromobacter sp. during Persistence in the Lungs of Cystic Fibrosis Patients.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 50 citations in OpenAlex.
- Early and matureBiofilm · 2026Article
- Differential Evolution ofPathogens (Basel, Switzerland) · 2026Article
- From an emerging pathogen to therapeutic challenges: advances inFrontiers in microbiology · 2026Review
- The cystic fibrosis pathogenJournal of medical microbiology · 2025Article
- Achromobacter xylosoxidans modulates Pseudomonas aeruginosa virulence through a complex multi-target competition.Scientific reports · 2025Article
- Defining antimicrobial susceptibility testing methods and breakpoints amongJournal of clinical microbiology · 2025Article
- Prevalence and variability of siderophore production in theMicrobiology spectrum · 2024Article
- Exoproducts of the Most CommonMicrobiology spectrum · 2023Article
- CompoundingViruses · 2023Article
- Bacterial virulence regulation through soluble peptidoglycan fragments sensing and response: knowledge gaps and therapeutic potential.FEMS microbiology reviews · 2023Article
- Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates ofMicrobiology spectrum · 2023Article
- Within-host evolution of bacterial pathogens during persistent infection of humans.Current opinion in microbiology · 2022Review
- Article
- Characterization of theFrontiers in cellular and infection microbiology · 2022Article
- Adaptive Interactions ofPathogens (Basel, Switzerland) · 2021Article
- Article
- Genomic characterization ofMicrobial genomics · 2021Article
- Review
- Transmission and Antibiotic Resistance ofJournal of clinical microbiology · 2021Article
- Complete Genome Sequence of Achromobacter xylosoxidans Myophage Mano.Microbiology resource announcements · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achromobacter species are increasingly isolated from the respiratory tract of cystic fibrosis patients and often a chronic infection is established. How Achromobacter sp. adapts to the human host remains uncharacterised. By comparing longitudinally collected isolates of Achromobacter sp. isolated from five CF patients, we have investigated the within-host evolution of clonal lineages. The majority of identified mutations were isolate-specific suggesting co-evolution of several subpopulations from the original infecting isolate. The largest proportion of mutated genes were involved in the general metabolism of the bacterium, but genes involved in virulence and antimicrobial resistance were also affected. A number of virulence genes required for initiation of acute infection were selected against, e.g. genes of the type I and type III secretion systems and genes related to pilus and flagellum formation or function. Six antimicrobial resistance genes or their regulatory genes were mutated, including large deletions affecting the repressor genes of an RND-family efflux pump and a beta-lactamase. Convergent evolution was observed for five genes that were all implicated in bacterial virulence. Characterisation of genes involved in adaptation of Achromobacter to the human host is required for understanding the pathogen-host interaction and facilitate design of future therapeutic interventions.
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