ArticleEinstein (Sao Paulo, Brazil)
Comparative analysis of survival between elderly and non-elderly severe sepsis and septic shock resuscitated patients.
Article in Einstein (Sao Paulo, Brazil). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Age-dependent differences in the association between blood interleukin-6 levels and mortality in patients with sepsis: a retrospective observational study.Journal of intensive care · 2025Article
- Usage of Meropenem Continuous Infusion for Treatment of Infectious Complications in Orthopedic Elderly Patients with Anemia: A Case Series.Medicina (Kaunas, Lithuania) · 2024Article
- Evaluation of Clinical Course and Outcomes of Severe Sepsis and Septic Shock in Elderly Patients.Journal of clinical practice and research · 2024Article
- Analysis of trends in sepsis mortality in Brazil and by regions from 2010 to 2019.Revista de saude publica · 2022Observational
- Evaluation and Predictors of Fluid Resuscitation in Patients With Severe Sepsis and Septic Shock.Critical care medicine · 2019Article
- Metabolomics Coupled with Transcriptomics Approach Deciphering Age Relevance in Sepsis.Aging and disease · 2019Article
- Observational
- The endotoxemia cardiac dysfunction is attenuated by AMPK/mTOR signaling pathway regulating autophagy.Biochemical and biophysical research communications · 2017Article
- Blood Lactate Levels Cutoff and Mortality Prediction in Sepsis-Time for a Reappraisal? a Retrospective Cohort Study.Shock (Augusta, Ga.) · 2016Article
- Role of TFEB Mediated Autophagy, Oxidative Stress, Inflammation, and Cell Death in Endotoxin Induced Myocardial Toxicity of Young and Aged Mice.Oxidative medicine and cellular longevity · 2016Article
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Authors and funding
5 authors.
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Abstract
objectiveTo compare outcomes between elderly (≥65 years old) and non-elderly (<65 years old) resuscitated severe sepsis and septic shock patients and determine predictors of death among elderly patients.
methodsRetrospective cohort study including 848 severe sepsis and septic shock patients admitted to the intensive care unit between January 2006 and March 2012.
resultsElderly patients accounted for 62.6% (531/848) and non-elderly patients for 37.4% (317/848). Elderly patients had a higher APACHE II score [22 (18-28)versus 19 (15-24); p<0.001], compared to non-elderly patients, although the number of organ dysfunctions did not differ between the groups. No significant differences were found in 28-day and in-hospital mortality rates between elderly and non-elderly patients. The length of hospital stay was higher in elderly compared to non-elderly patients admitted with severe sepsis and septic shock [18 (10-41)versus 14 (8-29) days, respectively; p=0.0001]. Predictors of death among elderly patients included age, site of diagnosis, APACHE II score, need for mechanical ventilation and vasopressors.
conclusionIn this study population early resuscitation of elderly patients was not associated with increased in-hospital mortality. Prospective studies addressing the long-term impact on functional status and quality of life are necessary.
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