ReviewSocial neuroscience2015
Social scaffolding of human amygdala-mPFCcircuit development.
Review in Social neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed.
- Threat, Emotion Dysregulation, and Parenting in a Clinical Sample of Children with Disruptive Behaviour.Child psychiatry and human development · 2026Article
- Network analysis of childhood trauma and meaning in life in adolescents with and without depression.BMC psychology · 2026Article
- Microbiome-behavior coupling shapes infant adaptation to early maternal unpredictability.Frontiers in microbiology · 2026Article
- Toward Understanding and Halting Legacies of Trauma.Biological psychiatry · 2025Review
- Association Between Smartphone Attachment and Mental Health in Adolescents.Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc · 2025Article
- It's Safe to Look: Maternal Touch Affects Infants' Fear Bias.Developmental science · 2025Article
- Altered activity within the social behavior neural network in adolescent rats following prenatal alcohol exposure and/or early-life adversity.Alcohol, clinical & experimental research · 2025Article
- Article
- Differential functional organization of amygdala-medial prefrontal cortex networks in macaque and human.Communications biology · 2024Article
- Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems.Frontiers in psychology · 2024Review
- Leveraging the developmental neuroscience of caregiving to promote resilience among youth exposed to adversity.Development and psychopathology · 2023Article
- Infant pain vs. pain with parental suppression: Immediate and enduring impact on brain, pain and affect.PloS one · 2023Article
- Examining resting-state network connectivity in children exposed to perinatal maternal adversity using anatomically weighted functional connectivity (awFC) analyses; A preliminary report.Frontiers in neuroscience · 2023Article
- Article
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
- The effects of social isolation stress and discrimination on mental health.Translational psychiatry · 2022Review
- Does pubertal stage mediate the association between family environment and structure and function of the amygdala-mPFC circuit? A replication study of the longitudinal ABCD cohort.Developmental cognitive neuroscience · 2022Article
- Early life stress and neural development: Implications for understanding the developmental effects of COVID-19.Cognitive, affective & behavioral neuroscience · 2022Review
- Prospective longitudinal associations between harsh parenting and corticolimbic function during adolescence.Development and psychopathology · 2022Article
- Brain functional connectivities that mediate the association between childhood traumatic events, and adult mental health and cognition.EBioMedicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Strong evidence indicates that reciprocal connections between the amygdala and the medial prefrontal cortex (mPFC) support fundamental aspects of emotional behavior in adulthood. However, this circuitry is slow to develop in humans, exhibiting immaturity in childhood. The argument is made that the development of this circuitry in humans is intimately associated with caregiving, such that parental availability during childhood provides important and enduring scaffolding of neuroaffective processes that ultimately form of the nature of the adult phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.