ArticlePain2016
Role of adult hippocampal neurogenesis in persistent pain.
Article in Pain, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Acupuncture treatment of vascular cognitive impairment through peripheral nerve stimulation pathway: a scoping review.Frontiers in aging neuroscience · 2025Pooled it
- The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.Pain · 2019Pooled it
- Benefits of resistance exercise in lean women with fibromyalgia: involvement of IGF-1 and leptin.BMC musculoskeletal disorders · 2017Trial
- Chronic ocular pain is associated with smaller selective hippocampal subfield in highly symptomatic patients.The journal of pain · 2026Article
- The characterization of Parkinson's disease related pain based on the classification system: The severity of neuropathic pain and the clinical profile of nociplastic pain.Clinical parkinsonism & related disorders · 2026Article
- Downregulation of Neuralized1 in the Hippocampal CA1 Through Reducing CPEB3 Ubiquitination Mediates Synaptic Plasticity Impairment and Cognitive Deficits in Neuropathic Pain.Neuroscience bulletin · 2025Article
- Recent Insights on Supraspinal Astrocytes in Chronic Pain.Neurochemical research · 2025Review
- CXCR2 modulates chronic pain comorbid depression in mice by regulating adult neurogenesis in the ventral dentate gyrus.Acta pharmacologica Sinica · 2025Article
- Experimental orthodontic pain drives anxiety state through the induction of alterations to the neuronal architecture in hippocampus.BMC neuroscience · 2025Article
- MeCP2 Modulates Depression-Like Behaviors Comorbid to Chronic Pain by Regulating Adult Hippocampal Neurogenesis.CNS neuroscience & therapeutics · 2025Article
- Investigating Brain Structure and Functional Alterations in the Transition from Acute to Chronic Neck Pain: A Resting-State fMRI Study.Journal of pain research · 2025Article
- Brain Amyloid-β Peptide Is Associated with Pain Intensity and Cognitive Dysfunction in Osteoarthritic Patients.International journal of molecular sciences · 2024Observational
- Article
- Probable chronic pain, brain structure, and Alzheimer's plasma biomarkers in older men.The journal of pain · 2024Article
- Hippocampus diffusivity abnormalities in classical trigeminal neuralgia.Pain reports · 2024Article
- Article
- Regulation of neuropathic pain by microglial Orai1 channels.Science advances · 2023Article
- Disentangling the neurological basis of chronic ocular pain using clinical, self-report, and brain imaging data: use of K-means clustering to explore patient phenotypes.Frontiers in neurology · 2023Article
- Coexistence of chronic hyperalgesia and multilevel neuroinflammatory responses after experimental SCI: a systematic approach to profiling neuropathic pain.Journal of neuroinflammation · 2022Article
- Effect of gabapentin on neurogenesis in hippocampal dentate gyrus of adult rats with co-disease of chronic pain and depression.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Article
1 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
The full role of adult hippocampal neurogenesis (AHN) remains to be determined, yet it is implicated in learning and emotional functions, and is disrupted in negative mood disorders. Recent evidence indicates that AHN is decreased in persistent pain consistent with the idea that chronic pain is a major stressor, associated with negative moods and abnormal memories. Yet, the role of AHN in development of persistent pain has remained unexplored. In this study, we test the influence of AHN in postinjury inflammatory and neuropathic persistent pain-like behaviors by manipulating neurogenesis: pharmacologically through intracerebroventricular infusion of the antimitotic AraC; ablation of AHN by x-irradiation; and using transgenic mice with increased or decreased AHN. Downregulating neurogenesis reversibly diminished or blocked persistent pain; oppositely, upregulating neurogenesis led to prolonged persistent pain. Moreover, we could dissociate negative mood from persistent pain. These results suggest that AHN-mediated hippocampal learning mechanisms are involved in the emergence of persistent pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.