ArticleGenome biology2015
Quantitative detection of rare interphase chromosome breaks and translocations by high-throughput imaging.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change.International journal of molecular sciences · 2023Review
- High-Throughput DNA FISH (hiFISH).Methods in molecular biology (Clifton, N.J.) · 2022Article
- Detection of ploidy and chromosomal aberrations in commercial oil palm using high-throughput SNP markers.Planta · 2021Article
- Cellular and genomic approaches for exploring structural chromosomal rearrangements.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- Article
- High-Throughput Imaging for the Discovery of Cellular Mechanisms of Disease.Trends in genetics : TIG · 2017Review
- Comparative analysis of 2D and 3D distance measurements to study spatial genome organization.Methods (San Diego, Calif.) · 2017Article
- Spectral imaging to visualize higher-order genomic organization.Nucleus (Austin, Tex.) · 2016Article
- Metadata management for high content screening in OMERO.Methods (San Diego, Calif.) · 2016Article
- Three Dimensional Organization of the Nucleus: adding DNA sequences to the big picture.Genome biology · 2015Article
- HIPMap: A High-Throughput Imaging Method for Mapping Spatial Gene Positions.Cold Spring Harbor symposia on quantitative biology · 2015Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
We report a method for the sensitive detection of rare chromosome breaks and translocations in interphase cells. HiBA-FISH (High-throughput break-apart FISH) combines high-throughput imaging with the measurement of the spatial separation of FISH probes flanking target genome regions of interest. As proof-of-principle, we apply hiBA-FISH to detect with high sensitivity and specificity rare chromosome breaks and translocations in the anaplastic large cell lymphoma breakpoint regions of NPM1 and ALK. This method complements existing approaches to detect translocations by overcoming the need for precise knowledge of translocation breakpoints and it extends traditional FISH by its quantitative nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.