ArticleInternational journal of geriatric psychiatry2016
Physical frailty in late-life depression is associated with deficits in speed-dependent executive functions.
Article in International journal of geriatric psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 4 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association between frailty and adverse outcomes in patients undergoing maintenance hemodialysis: a systematic review and meta-analysis.Renal failure · 2024Pooled it
- Association between frailty and depression: A bidirectional Mendelian randomization study.Science advances · 2023Pooled it
- Frailty and Cognitive Function in Older Adults: A Systematic Review and Meta-Analysis of Cross-Sectional Studies.Neuropsychology review · 2022Pooled it
- Transcranial magnetic stimulation (TMS) for geriatric depression.Ageing research reviews · 2022Pooled it
- Article
- Among 69,178 UK Residents Ages 65+ Years, Frailty Associates Significantly With Lifestyle Behaviors and Depression: A Cross-Sectional Study.Health science reports · 2025Article
- Developing and validating machine learning-based prediction models for frailty occurrence in those with chronic obstructive pulmonary disease.Journal of thoracic disease · 2024Article
- Inflammaging and Frailty in Immune-Mediated Rheumatic Diseases: How to Address and Score the Issue.Clinical reviews in allergy & immunology · 2023Review
- Physical Frailty and Cognitive Function among Older Chinese Adults: The Mediating Roles of Activities of Daily Living Limitations and Depression.The Journal of frailty & aging · 2023Article
- Relationship between Frailty and Depression in a Population from North-Eastern Romania.International journal of environmental research and public health · 2022Article
- Bidirectional Longitudinal Study of Frailty and Depressive Symptoms Among Older Chinese Adults.Frontiers in aging neuroscience · 2022Article
- Depression in frail older adults: Associations and gender difference.Northern clinics of Istanbul · 2022Article
- Self-management of depression and anxiety amongst frail older adults in the United Kingdom: A qualitative study.PloS one · 2022Article
- Assessment of the Psychophysical Sphere and Functional Status of Women Aged 75-90 Living Alone and in Nursing Homes.International journal of environmental research and public health · 2021Article
- Lockdown Effects on Healthy Cognitive Aging During the COVID-19 Pandemic: A Longitudinal Study.Frontiers in psychology · 2021Article
- Supporting frail older people with depression and anxiety: a qualitative study.Aging & mental health · 2020Article
- Clinical and Neuropsychological Correlates of Prefrailty Syndrome.Frontiers in medicine · 2020Article
- Impact of anxio-depressive symptoms and cognitive function on oral anticancer therapies adherence.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019Article
- Depressive symptoms, frailty, and mortality among dialysis patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2019Article
- Cognitive frailty among Malaysian older adults: baseline findings from the LRGS TUA cohort study.Clinical interventions in aging · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
objectiveThe aim of this study was to examine the association between physical frailty and neurocognitive performance in late-life depression (LLD).
methodsCross-sectional design using baseline data from a treatment study of late-life depression was used in this study. Individuals aged 60 years and older were diagnosed with major depressive disorder at time of assessment (N = 173). All participants received clinical assessment of depression and completed neuropsychological testing during a depressive episode. Physical frailty was assessed using an adaptation of the FRAIL scale. Neuropsychological domains were derived from a factor analysis that yielded three factors: (i) speeded executive and fluency, (ii) episodic memory, and (iii) working memory. Associations were examined with bivariate tests and multivariate models.
resultsDepressed individuals with a FRAIL score >1 had worse performance than nonfrail depressed across all three factors; however, speeded executive and fluency was the only factor that remained significant after controlling for depression symptom severity and demographic characteristics.
conclusionsAlthough physical frailty is associated with broad neurocognitive deficits in LLD, it is most robustly associated with deficits in speeded executive functions and verbal fluency. Causal inferences are limited by the cross-sectional design, and future research would benefit from a comparison group of nondepressed older adults with similar levels of frailty. Research is needed to understand the mechanisms underlying associations among depression symptoms, physical frailty, and executive dysfunction and how they are related to the cognitive and symptomatic course of LLD.
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