ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2015
Syntactic processing as a marker for cognitive impairment in amyotrophic lateral sclerosis.
Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- The Study of Language in the Amyotrophic Lateral Sclerosis - Frontotemporal Spectrum Disorder: a Systematic Review of Findings and New Perspectives.Neuropsychology review · 2018Pooled it
- Comparison of in-person vs. remote administration of cognitive screening tools for people with ALS.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Patterns of Language Impairment in Early Amyotrophic Lateral Sclerosis.Neurology. Clinical practice · 2021Article
- Cognition and behaviour in frontotemporal dementia with and without amyotrophic lateral sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2020Article
- Automated analysis of natural speech in amyotrophic lateral sclerosis spectrum disorders.Neurology · 2020Article
- Evolution of white matter damage in amyotrophic lateral sclerosis.Annals of clinical and translational neurology · 2020Article
- Psychometric Properties of Cognitive Assessment in Amyotrophic Lateral Sclerosis: A Systematic Review.Patient related outcome measures · 2020Review
- Speech network regional involvement in bulbar ALS: a multimodal structural MRI study.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2019Article
- Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2019Article
- Clinical and neuroimaging investigations of language disturbance in frontotemporal dementia-motor neuron disease patients.Journal of neurology · 2019Article
- Dissecting the pathobiology of altered MRI signal in amyotrophic lateral sclerosis: A post mortem whole brain sampling strategy for the integration of ultra-high-field MRI and quantitative neuropathology.BMC neuroscience · 2018Article
- Clinical and Radiological Markers of Extra-Motor Deficits in Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
- Communication Matters-Pitfalls and Promise of Hightech Communication Devices in Palliative Care of Severely Physically Disabled Patients With Amyotrophic Lateral Sclerosis.Frontiers in neurology · 2018Review
- Action Semantics at the Bottom of the Brain: Insights From Dysplastic Cerebellar Gangliocytoma.Frontiers in psychology · 2018Article
- Examining the language and behavioural profile in FTD and ALS-FTD.Journal of neurology, neurosurgery, and psychiatry · 2017Article
- Amyotrophic lateral sclerosis - frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2017Review
- Connected Speech in Neurodegenerative Language Disorders: A Review.Frontiers in psychology · 2017Review
- Formal Semantics in the Neurology Clinic: Atypical Understanding of Aspectual Coercion in ALS Patients.Frontiers in psychology · 2016Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 1 country.
Funding
Abstract
Despite recent interest in cognitive changes in patients with amyotrophic lateral sclerosis (ALS), investigations of language function looking at the level of word, sentence and discourse processing are relatively scarce. Data were obtained from 26 patients with sporadic ALS and 26 healthy controls matched for age, education, gender, anxiety, depression and executive function performance. Standardized language tasks included confrontation naming, semantic access, and syntactic comprehension. Quantitative production analysis (QPA) was used to analyse connected speech samples of the Cookie Theft picture description task. Results showed that the ALS patients were impaired on standardized measures of grammatical comprehension and action/verb semantics. At the level of discourse, ALS patients were impaired on measures of syntactic complexity and fluency; however, the latter could be better explained by disease related factors. Discriminant analysis revealed that syntactic measures differentiated ALS patients from controls. In conclusion, patients with ALS exhibit deficits in receptive and expressive language on tasks of comprehension and connected speech production, respectively. Our findings suggest that syntactic processing deficits seem to be the predominant feature of language impairment in ALS and that these deficits can be detected by relatively simple language tests.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.