ArticleAmyotrophic lateral sclerosis & frontotemporal degeneration2015
Eye-tracking in amyotrophic lateral sclerosis: A longitudinal study of saccadic and cognitive tasks.
Article in Amyotrophic lateral sclerosis & frontotemporal degeneration, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Exploring amyotrophic lateral sclerosis through the visual system: A systematic review.European journal of neurology · 2024Pooled it
- Oculomotor atypicalities in motor neurone disease: a systematic review.Frontiers in neuroscience · 2024Pooled it
- The effectiveness of eye tracking in the diagnosis of cognitive disorders: A systematic review and meta-analysis.PloS one · 2021Pooled it
- Atypical features including acquired oculomotor apraxia inJournal of neuromuscular diseases · 2026Article
- Multi-regional transcriptomic profiling reveals divergent molecular mechanisms in ALS-related neurodegeneration.PLoS genetics · 2026Article
- The Canadian multi-ethnic research on aging (CAMERA) study: Design, participant characteristics, and preliminary findings.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Observational
- The Epidemiology of Primary Lateral Sclerosis: Results from a Population-Based Cohort.Annals of neurology · 2026Article
- The Impact of Bulbar and Upper Motor Neuron Involvement on Oculomotor Movement in Amyotrophic Lateral Sclerosis.Brain and behavior · 2025Article
- Observational
- The Basis of Cognitive and Behavioral Dysfunction in Amyotrophic Lateral Sclerosis.Brain and behavior · 2024Review
- Supra- and infra-tentorial degeneration patterns in primary lateral sclerosis: a multimodal longitudinal neuroradiology study.Journal of neurology · 2024Article
- Primary Lateral Sclerosis: An Overview.Journal of clinical medicine · 2024Review
- ETMT: A Tool for Eye-Tracking-Based Trail-Making Test to Detect Cognitive Impairment.Sensors (Basel, Switzerland) · 2023Article
- Blink-To-Live eye-based communication system for users with speech impairments.Scientific reports · 2023Article
- EyeT4Empathy: Dataset of foraging for visual information, gaze typing and empathy assessment.Scientific data · 2022Article
- Multimodal in vivo staging in amyotrophic lateral sclerosis using artificial intelligence.Annals of clinical and translational neurology · 2022Article
- Modeling seeding and neuroanatomic spread of pathology in amyotrophic lateral sclerosis.NeuroImage · 2022Article
- Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis.Brain sciences · 2022Article
- Motor-Independent Cognitive Testing in Motor Degenerative Diseases.Journal of clinical medicine · 2022Article
- Exploratory evaluation of an eye-tracking system in patients with advanced spinal muscular atrophy type I receiving nusinersen.Frontiers in neurology · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A relative preservation of eye movements is notable in ALS, but saccadic functions have not been studied longitudinally. ALS overlaps with FTD, typically involving executive dysfunction, and eye-tracking offers additional potential for the assessment of extramotor pathology where writing and speaking are both impaired. Eye-tracking measures (including anti-saccade, trail-making and visual search tasks) were assessed at six-monthly intervals for up to two years in a group of ALS (n = 61) and primary lateral sclerosis (n = 7) patients, compared to healthy age-matched controls (n = 39) assessed on a single occasion. Task performance was explored speculatively in relation to resting-state functional MRI (R-FMRI) network connectivity. Results showed that ALS patients were impaired on executive and visual search tasks despite normal basic saccadic function, and impairments in the PLS patients were unexpectedly often more severe. No significant progression was detected longitudinally in either group. No changes in R-FMRI network connectivity were identified in relation to patient performance. In conclusion, eye-tracking offers an objective means to assess extramotor cerebral involvement in ALS. The relative resistance of pure oculomotor function is confirmed, and higher-level executive impairments do not follow the same rate of decline as physical disability. PLS patients may have more cortical dysfunction than has been previously appreciated.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.