Evidence map›Paper›PMID 26312544›Full record

ArticleThe journal of spinal cord medicine2016

Association between 25(OH)-vitamin D and testosterone levels: Evidence from men with chronic spinal cord injury.

Arcangelo Barbonetti, Maria Rosaria C Vassallo, Giorgio Felzani, Sandro Francavilla, Felice Francavilla

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of spinal cord medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. The Role of Vitamins in Spinal Cord Injury: Mechanisms and Benefits.Oxidative medicine and cellular longevity · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Recurrent priapism in spinal cord injury: A case report.The journal of spinal cord medicine · 2021
    Article
  13. Article
  14. Article
  15. Laboratory evaluation of secondary causes of bone loss in Veterans with spinal cord injury and disorders.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2019
    Article
  16. Article
  17. Review
  18. Article
  19. Effectiveness of two vitamin DSpinal cord series and cases · 2018
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Arcangelo Barbonettia Department of Life, Health and Environment Sciences , University of L'Aquila , 67100 L'Aquila , Italy.
Maria Rosaria C Vassalloa Department of Life, Health and Environment Sciences , University of L'Aquila , 67100 L'Aquila , Italy.
Giorgio Felzanib San Raffaele Sulmona Institute , 67039 Sulmona , Italy.
Sandro Francavillaa Department of Life, Health and Environment Sciences , University of L'Aquila , 67100 L'Aquila , Italy.
Felice Francavillaa Department of Life, Health and Environment Sciences , University of L'Aquila , 67100 L'Aquila , Italy.
University of L'Aquila · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAs an independent linear association between 25-hydroxyvitamin D (25(OH)D) and testosterone levels is controversial, this study aimed to explore this topic in men with chronic spinal cord injury (SCI), who exhibit a high prevalence of both androgen and vitamin D deficiency.

designForty-nine men with chronic SCI consecutively admitted to a rehabilitation program underwent clinical/biochemical evaluations.

resultsDeficiency of 25(OH)D (<20 ng/mL) was found in 36 patients (73.5%). They exhibited significantly lower total testosterone and free testosterone levels, higher parathyroid hormone (PTH) and HOMA-IR, a poorer functional independence degree, and were engaged in poorer weekly leisure time physical activity (LTPA). Significant correlates of 25(OH)D levels were: total testosterone, free testosterone, PTH, functional independence degree and weekly LTPA. At the linear regression models, lower 25(OH)D levels were associated with both lower total and free testosterone after adjustment for age, smoking, alcohol consumption, comorbidities and HOMA-IR. However, after full adjustment, also including functional independence degree, BMI and LTPA, only the association of lower 25(OH)D with lower free testosterone was still significant.

conclusionIn men with SCI, 25(OH)D correlates with total and free testosterone and exhibits an independent linear association with free testosterone. Regardless of this independent link, hypovitaminosis D and androgen deficiency are markers of poor health, sharing common risk factors to take into account in the rehabilitative approach to patients with SCI.

Indexed as

AdultExerciseHumansInsulinMaleMiddle AgedParathyroid HormoneSpinal Cord InjuriesTestosteroneVitamin D25-hydroxyvitamin DInsulinParathyroid HormoneTestosteroneVitamin DAndrogen deficiencyHypogonadismHypovitaminosis DParaplegiaTetraplegia

Identifiers

PMID26312544
PMCPMC5073757
OpenAlexW1928172231

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.