ArticleACS applied materials & interfaces2015
Triggerable Degradation of Polyurethanes for Tissue Engineering Applications.
Article in ACS applied materials & interfaces, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 70 citations in OpenAlex.
- GSH-responsive polyurethane/PBAT blend films: degradation kinetics, ecotoxicity screening, and governance-carbon couplingRSC advances · 2026Article
- Bio-inspired programmable assembly of shape-memory and blood-reinforced cryogel for hemostasis and functional liver regeneration.Materials today. Bio · 2026Article
- Electrospun polyurethane-eggshell membrane hybrid nanofibrous scaffolds for enhanced fibroblast adhesion and growth in skin tissue engineering.Scientific reports · 2026Article
- Exploring Electrospun Scaffold Innovations in Cardiovascular Therapy: A Review of Electrospinning in Cardiovascular Disease.Bioengineering (Basel, Switzerland) · 2024Review
- Cell-scaffold interactions in tissue engineering for oral and craniofacial reconstruction.Bioactive materials · 2023Article
- Rational design of biodegradable thermoplastic polyurethanes for tissue repair.Bioactive materials · 2022Review
- Lung Cancer Targeted Chemoradiotherapy via Dual-Stimuli Responsive Biodegradable Core-Shell Nanoparticles.Pharmaceutics · 2022Article
- Biocompatibility studies of polyurethane electrospun membranes based on arginine as chain extender.Journal of materials science. Materials in medicine · 2021Article
- Waterborne Polyurethane Dispersions and Thin Films: Biodegradation and Antimicrobial Behaviors.Molecules (Basel, Switzerland) · 2021Review
- Optimizing Anisotropic Polyurethane Scaffolds to Mechanically Match with Native Myocardium.ACS biomaterials science & engineering · 2020Article
- Glutathione-responsive biodegradable polyurethane nanoparticles for lung cancer treatment.Journal of controlled release : official journal of the Controlled Release Society · 2020Article
- Facile Fabrication of High-Contrast and Light-Colored Marking on Dark Thermoplastic Polyurethane Materials.ACS omega · 2019Article
- Electrospinning and Electrospun Nanofibers: Methods, Materials, and Applications.Chemical reviews · 2019Review
- Enhancing anti-thrombogenicity of biodegradable polyurethanes through drug molecule incorporation.Journal of materials chemistry. B · 2018Article
- Highly Elastic Biodegradable Single-Network Hydrogel for Cell Printing.ACS applied materials & interfaces · 2018Article
- Surface functionalization of polyurethane scaffolds mimicking the myocardial microenvironment to support cardiac primitive cells.PloS one · 2018Article
- Low-Initial-Modulus Biodegradable Polyurethane Elastomers for Soft Tissue Regeneration.ACS applied materials & interfaces · 2017Article
- Development of dopant-free conductive bioelastomers.Scientific reports · 2016Article
- A Novel Electrostimulated Drug Delivery System Based on PLLA Composites Exploiting the Multiple Functions of Graphite Nanoplatelets.ACS applied materials & interfaces · 2016Article
- Synthesis and characterization of conductive, biodegradable, elastomeric polyurethanes for biomedical applications.Journal of biomedical materials research. Part A · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Tissue engineered and bioactive scaffolds with different degradation rates are required for the regeneration of diverse tissues/organs. To optimize tissue regeneration in different tissues, it is desirable that the degradation rate of scaffolds can be manipulated to comply with various stages of tissue regeneration. Unfortunately, the degradation of most degradable polymers relies solely on passive controlled degradation mechanisms. To overcome this challenge, we report a new family of reduction-sensitive biodegradable elastomeric polyurethanes containing various amounts of disulfide bonds (PU-SS), in which degradation can be initiated and accelerated with the supplement of a biological product: antioxidant-glutathione (GSH). The polyurethanes can be processed into films and electrospun fibrous scaffolds. Synthesized materials exhibited robust mechanical properties and high elasticity. Accelerated degradation of the materials was observed in the presence of GSH, and the rate of such degradation depends on the amount of disulfide present in the polymer backbone. The polymers and their degradation products exhibited no apparent cell toxicity while the electrospun scaffolds supported fibroblast growth in vitro. The in vivo subcutaneous implantation model showed that the polymers prompt minimal inflammatory responses, and as anticipated, the polymer with the higher disulfide bond amount had faster degradation in vivo. This new family of polyurethanes offers tremendous potential for directed scaffold degradation to promote maximal tissue regeneration.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.