ArticleHepatobiliary surgery and nutrition2015
Intestinal microbial metabolism of phosphatidylcholine: a novel insight in the cardiovascular risk scenario.
Article in Hepatobiliary surgery and nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Effects of Probiotic Supplementation on Trimethylamine-N-Oxide Plasma Levels in Hemodialysis Patients: a Pilot Study.Probiotics and antimicrobial proteins · 2019Trial
- Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities.Pharmacological reviews · 2026Review
- Metabolic mediators: microbial-derived metabolites as key regulators of anti-tumor immunity, immunotherapy, and chemotherapy.Frontiers in immunology · 2024Review
- Fecal microbiota transplantation ameliorates atherosclerosis in mice with C1q/TNF-related protein 9 genetic deficiency.Experimental & molecular medicine · 2022Article
- Role of the microbiome and its metabolites in ankylosing spondylitis.Frontiers in immunology · 2022Review
- Microbial-derived antigens and metabolites in spondyloarthritis.Seminars in immunopathology · 2021Review
- Understanding the Effects of Gut Microbiota Dysbiosis on Nonalcoholic Fatty Liver Disease and the Possible Probiotics Role: Recent Updates.International journal of biological sciences · 2021Review
- Trimethylamine-Renal failure · 2020Article
- Comprehensive Examination of the Mouse Lung Metabolome FollowingJournal of proteome research · 2020Article
- Circulating metabolites from the choline pathway and acute coronary syndromes in a Chinese case-control study.Nutrition & metabolism · 2020Article
- Targeted metabolomic analysis of plasma metabolites in patients with coronary heart disease in southern China.Medicine · 2019Article
- Astragaloside IV reversed the autophagy and oxidative stress induced by the intestinal microbiota of AIS in mice.Journal of microbiology (Seoul, Korea) · 2018Article
- Methodological considerations for the identification of choline and carnitine-degrading bacteria in the gut.Methods (San Diego, Calif.) · 2018Review
- Alterations in gut microbial function following liver transplant.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2018Article
- Cross-Talk between Gut Microbiota and Heart via the Routes of Metabolite and Immunity.Gastroenterology research and practice · 2018Review
- Review
- Metagenomic data-mining reveals contrasting microbial populations responsible for trimethylamine formation in human gut and marine ecosystems.Microbial genomics · 2016Article
- Metabolic Interactions in the Gastrointestinal Tract (GIT): Host, Commensal, Probiotics, and Bacteriophage Influences.Microorganisms · 2015Review
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Intestinal microbiota is a "dynamic organ" influencing host metabolism, nutrition, physiology and immune system. Among its several interactions, the role of a phosphatidylcholine metabolite derived by gut flora activity, i.e., trimethylamine-N-oxide (TMAO), allows perceiving a novel insight in the cardiovascular risk scenario, being a strong predictor of this condition. Based on current reports, including the paper of Tang et al., we describe here: the possible role of intestinal microbiota in cardiovascular risk as well as potential interventions to reduce gut flora TMAO production by diet, probiotics and antibiotics. Finally, we highlight the possibility of evaluating, monitoring and modulating TMAO in order to use its serum levels as a marker of cardiovascular risk in the next future, when the need of controlled studies on large series will be satisfied.
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