Evidence map›Paper›PMID 26312240›Full record

ArticleThe Journal of frailty & aging2015

FUNCTIONAL LIMITATIONS AND ADIPOKINES IN HIV-INFECTED OLDER ADULTS.

K N Shah, Z Majeed, H Yang, J J Guido, T N Hilton, O Polesskaya, W J Hall, A E Luque

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in The Journal of frailty & aging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Enhancing physical function in HIV-infected older adults: A randomized controlled clinical trial.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2016
    Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

K N ShahDivision of Geriatrics and Aging, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Z MajeedDivision of Geriatrics and Aging, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
H YangDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
J J GuidoDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
T N HiltonDepartment of Physical Therapy, Ithaca College, Rochester, New York.
O PolesskayaDepartment of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York.
W J HallDivision of Geriatrics and Aging, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
A E LuqueDivision of Infectious Disease, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York.
University of Rochester · USIthaca College · US

Funding

Virology/Immunology CoreP30AI078498 · NIAID · UNIVERSITY OF ROCHESTER · PI DEWHURST, STEPHEN · 2008 to 2018
$14.6M
Research Training in Geriatrics and GerontologyT32AG020493 · NIA · UNIVERSITY OF ROCHESTER · PI HALL, WILLIAM JOHN · 2005 to 2009
$1.2M
Feasibility of an Exercise Intervention in HIV+ Older Adults with Central ObesityK23AG043319 · NIA · UNIVERSITY OF ROCHESTER · PI SHAH, KRUPA N. · 2013 to 2016
$602k
NIAID NIH HHS P30 AI078498NIA NIH HHS K23 AG043319NIA NIH HHS T32 AG020493
6 · The paper itself

Abstract

backgroundThere is a significant increase in the number of HIV-infected older adults (HOA). This population may experience functional decline at a much younger age. Little is known about the relationship between functional limitations and systemic adipokines in HOA.

objectiveOur study aimed to evaluate the relationship between functional limitations and systemic adipokine levels in HOA population.

designCross-sectional.

settingAcademic hospital-based infectious disease clinic.

participantsThe study investigated community-dwelling HIV-infected adults >50 years old and compared this group with age, gender and BMI comparable healthy controls. MEASUREMENTS: We measured functional status, body composition and plasma concentrations of adipokines.

resultsFifty-four HOA were studied (mean: age 57 years, BMI 29 kg/m2, CD4 604, duration of HIV 17 years) and compared with thirty-two age, gender and BMI comparable healthy controls. The HOA group showed significantly higher functional limitations compared to the age, gender and BMI comparable controls (p<0.05). Levels of adipokines were significantly different between the two groups (p<0.05). Multiple regression analyses indicated that adiponectin and visfatin were significantly correlated with several physical function measures after controlling for age, sex, and metabolic comorbidities. Adiponectin was negatively correlated with functional limitations, and this relationship was stronger in the control group compared to the HOA group. Conversely, visfatin was positively correlated with functional limitations only in the HOA group.

conclusionHOA have significant functional limitations and alteration in adipokine levels compared to controls. Adiponectin and visfatin were associated with functional limitations. Visfatin was a correlate of physical function only in the HOA group. Prospective longitudinal studies could provide further insight on the role of adipokines in HIV-related functional decline.

Indexed as

adipokinesfat redistributionHIVolder adultsphysical function

Identifiers

PMID26312240
PMCPMC4547479
OpenAlexW2442741860

What OpenQuestion holds

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LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.