Evidence map›Paper›PMID 26312014›Full record

ArticleJournal of receptor, ligand and channel research

mTOR signaling in mice with dysfunctional cardiac ryanodine receptor ion channel.

Tai-Qin Huang, Min-Xu Zou, Daniel A Pasek, Gerhard Meissner

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of receptor, ligand and channel research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Molecular biomarkers in cardiac hypertrophy.Journal of cellular and molecular medicine · 2019
    Review
  3. MicroRNA-96 promotes myocardial hypertrophy by targeting mTOR.International journal of clinical and experimental pathology · 2015
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tai-Qin HuangDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.
Min-Xu ZouDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.
Daniel A PasekDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.
Gerhard MeissnerDepartment of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · US

Funding

Ryanodine receptor in cardiac hypertrophy and heart failureR01HL073051 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MEISSNER, GERHARD W · 2003 to 2013
$3.5M
NHLBI NIH HHS R01 HL073051
6 · The paper itself

Abstract

Simultaneous substitution of three amino acid residues in the calmodulin binding domain (W3587A/L3591D/F3603A, ADA) of the cardiac ryanodine receptor ion channel (RyR2) impairs calmodulin inhibition of RyR2 and causes cardiac hypertrophy and early death of

Indexed as

calmodulincardiac hypertrophyrapamycinRyR2

Identifiers

PMID26312014
PMCPMC4547478
OpenAlexW1840506437

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.