Evidence map›Paper›PMID 26311959›Full record

ArticleJournal of physical therapy science2015

Does aerobic exercise affect the hypothalamic-pituitary-adrenal hormonal response in patients with fibromyalgia syndrome?

Aysun Genc, Birkan Sonel Tur, Yesim Kurtais Aytur, Derya Oztuna, Murat Faik Erdogan

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of physical therapy science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04500444 (Effects of Blood Flow Restricted Aerobic Exercise on Pain, Functional Status, Quality of Life, and Hormonal Response to Exercise in Fibromyalgia Patients - Randomized Controlled Trial), which is not on this map. Cited by 19 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04500444 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Effects of Blood Flow Restricted Aerobic Exercise on Pain, Functional Status, Quality of Life, and Hormonal Response to Exercise in Fibromyalgia Patients - Randomized Controlled Trial

TypeinterventionalSponsorIstanbul UniversityRan2019 to 2020Enrolled50ConditionsFibromyalgiaArmsexercise training
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Flexibility exercise training for adults with fibromyalgia.The Cochrane database of systematic reviews · 2019
    Pooled it
  5. Mixed exercise training for adults with fibromyalgia.The Cochrane database of systematic reviews · 2019
    Pooled it
  6. Whole body vibration exercise training for fibromyalgia.The Cochrane database of systematic reviews · 2017
    Pooled it
  7. Aerobic exercise training for adults with fibromyalgia.The Cochrane database of systematic reviews · 2017
    Pooled it
  8. Trial
  9. Article
  10. Review
  11. Fibromyalgia, Pain, and Physical Activity: A Bibliometric Analysis.International journal of environmental research and public health · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Aysun GencPhysiotherapy Programme, Ankara University Vocational School of Haymana, Turkey.
Birkan Sonel TurDepartment of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Turkey.
Yesim Kurtais AyturDepartment of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Turkey.
Derya OztunaDepartment of Biostatistics, Ankara University Faculty of Medicine, Turkey.
Murat Faik ErdoganDepartment of Endocrinology and Metabolism, Ankara University Faculty of Medicine, Turkey.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

[Purpose] The hypothalamic-pituitary-adrenal (HPA) axis in the etiopathogenesis of fibromyalgia is not clear. This study aimed to analyze the effects of a 6-week aerobic exercise program on the HPA axis in patients with fibromyalgia and to investigate the effects of this program on the disease symptoms, patients' fitness, disability, and quality of life. [Subjects and Methods] Fifty fibromyalgia patients were randomized to Group 1 (stretching and flexibility exercises at home for 6 weeks) and Group 2 (aerobic exercise three times a week and the same at-home exercises as Group 1 for 6 weeks). Serum levels of cortisol, adrenocorticotropic hormone, insulin-like growth factor-1, and growth hormone were analyzed at baseline and at the end of, and 1 hr after an exercise stress test. [Results] Group 2 showed better improvement in morning stiffness duration and pain. Growth hormone levels significantly increased after intervention and cortisol levels significantly decreased at time-time interaction in both groups. No significant differences in adrenocorticotropic hormone and insulin-like growth factor-1 were found. [Conclusion] The results of this study seem to support the hypothesis that there is a dysregulation of the HPA axis in patients with FM, and that a six-week exercise program can influence symptoms and affect the HPA axis hormones.

Indexed as

Aerobic exerciseFibromyalgiaHypothalamic-pituitary-adrenal axis

Identifiers

PMID26311959
PMCPMC4540854

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.