Evidence map›Paper›PMID 26311889›Full record

ArticleJournal of virology2015

Infectious Bursal Disease Virus VP3 Upregulates VP1-Mediated RNA-Dependent RNA Replication.

Diego Ferrero, Damià Garriga, Aitor Navarro, José F Rodríguez, Núria Verdaguer

Abstract read
In one paragraph

Article in Journal of virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Diego FerreroCentro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain Institut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain.
Damià GarrigaCentro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain.
Aitor NavarroMRC-University of Glasgow, Centre for Virus Research, Glasgow, Scotland, United Kingdom.
José F RodríguezCentro Nacional de Biotecnología (CSIC), Cantoblanco, Madrid, Spain jfrodrig@cnb.csic.es nvmcri@ibmb.csic.es.
Núria VerdaguerInstitut de Biologia Molecular de Barcelona (CSIC), Parc Científic de Barcelona, Barcelona, Spain jfrodrig@cnb.csic.es nvmcri@ibmb.csic.es.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Genome replication is a critical step in virus life cycles. Here, we analyzed the role of the infectious bursal disease virus (IBDV) VP3, a major component of IBDV ribonucleoprotein complexes, on the regulation of VP1, the virus-encoded RNA-dependent RNA polymerase (RdRp). Data show that VP3, as well as a peptide mimicking its C-terminal domain, efficiently stimulates the ability of VP1 to replicate synthetic single-stranded RNA templates containing the 3' untranslated regions (UTRs) from the IBDV genome segments.

Indexed as

Gene Expression Regulation, EnzymologicGene Expression Regulation, ViralInfectious bursal disease virusPolymerizationRNA, ViralViral Structural ProteinsVirus ReplicationRNA, ViralViral Structural ProteinsVP1 protein, infectious bursal disease virusVP3 protein, infectious bursal disease virus

Identifiers

PMID26311889
PMCPMC4621117

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.