ArticleProceedings. Biological sciences2015
Regressive evolution of the arthropod tritocerebral segment linked to functional divergence of the Hox gene labial.
Article in Proceedings. Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 40 citations in OpenAlex.
- Gene and Genome Duplication in Spiders.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2025Review
- The genome of a sea spider corroborates a shared Hox cluster motif in arthropods with a reduced posterior tagma.BMC biology · 2025Article
- Whole Genome Duplication in the Genomics Era: The Hidden Gems in Invertebrates?Genome biology and evolution · 2025Review
- The CambrianProceedings. Biological sciences · 2024Article
- An atlas of spider development at single-cell resolution provides new insights into arthropod embryogenesis.EvoDevo · 2024Article
- Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments.Molecular biology and evolution · 2023Article
- Article
- Echiuran Hox genes provide new insights into the correspondence between Hox subcluster organization and collinearity pattern.Proceedings. Biological sciences · 2022Article
- Eggs to long-legs: embryonic staging of the harvestman Phalangium opilio (Opiliones), an emerging model arachnid.Frontiers in zoology · 2022Article
- Widespread retention of ohnologs in key developmental gene families following whole-genome duplication in arachnopulmonates.G3 (Bethesda, Md.) · 2021Article
- The genome of a daddy-long-legs (Opiliones) illuminates the evolution of arachnid appendages.Proceedings. Biological sciences · 2021Article
- Anterior Hox Genes and the Process of Cephalization.Frontiers in cell and developmental biology · 2021Review
- Candidate gene screen for potential interaction partners and regulatory targets of the Hox gene labial in the spider Parasteatoda tepidariorum.Development genes and evolution · 2020Article
- six3 acts upstream of foxQ2 in labrum and neural development in the spider Parasteatoda tepidariorum.Development genes and evolution · 2020Article
- Article
- Homeobox Gene Duplication and Divergence in Arachnids.Molecular biology and evolution · 2018Article
- The house spider genome reveals an ancient whole-genome duplication during arachnid evolution.BMC biology · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intercalary segment is a limbless version of the tritocerebral segment and is present in the head of all insects, whereas other extant arthropods have retained limbs on their tritocerebral segment (e.g. the pedipalp limbs in spiders). The evolutionary origin of limb loss on the intercalary segment has puzzled zoologists for over a century. Here we show that an intercalary segment-like phenotype can be created in spiders by interfering with the function of the Hox gene labial. This links the origin of the intercalary segment to a functional change in labial. We show that in the spider Parasteatoda tepidariorum the labial gene has two functions: one function in head tissue maintenance that is conserved between spiders and insects, and a second function in pedipalp limb promotion and specification, which is only present in spiders. These results imply that labial was originally crucial for limb formation on the tritocerebral segment, but that it has lost this particular subfunction in the insect ancestor, resulting in limb loss on the intercalary segment. Such loss of a subfunction is away to avoid adverse pleiotropic effects normally associated with mutations in developmental genes, and may thus be a common mechanism to accelerate regressive evolution.
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