ArticleScientific reports2015
An efficient system for intracellular delivery of beta-lactam antibiotics to overcome bacterial resistance.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 85 citations in OpenAlex.
- Novel nucleoside analogs exhibit potent intracellular andMicrobiology spectrum · 2026Article
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- Enhancing the therapeutical potential of metalloantibiotics using nano-based delivery systems.Beilstein journal of nanotechnology · 2025Review
- Synthetic Approaches, Properties, and Applications of Acylals in Preparative and Medicinal Chemistry.Molecules (Basel, Switzerland) · 2024Review
- Drug delivery strategies for antibiofilm therapy.Nature reviews. Microbiology · 2023Review
- Influence of silver ion release on the inactivation of antibiotic resistant bacteria using light-activated silver nanoparticles.Materials advances · 2022Article
- β-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward.Frontiers in microbiology · 2022Review
- Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy.Journal for immunotherapy of cancer · 2021Article
- Inorganic nanohybrids combat antibiotic-resistant bacteria hiding within human macrophages.Nanoscale · 2021Article
- New Nanoparticle Formulation for Cyclosporin A: In Vitro Assessment.Pharmaceutics · 2021Article
- Boosting nanotoxicity to combat multidrug-resistant bacteria in pathophysiological environments.Nanoscale advances · 2020Article
- Article
- Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations.Pharmaceutics · 2020Review
- Lipid oligonucleotides as a new strategy for tackling the antibiotic resistance.Scientific reports · 2020Article
- ArtinM Grafted Phospholipid Nanoparticles for Enhancing Antibiotic Cellular Uptake Against Intracellular Infection.International journal of nanomedicine · 2020Article
- Combating Intracellular Pathogens with Nanohybrid-Facilitated Antibiotic Delivery.International journal of nanomedicine · 2020Article
- Boron doped silver-copper alloy nanoparticle targeting intracellular S. aureus in bone cells.PloS one · 2020Article
- Article
- Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics.ACS infectious diseases · 2019Review
- Use of ceragenins as a potential treatment for urinary tract infections.BMC infectious diseases · 2019Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "Golden era" of antibiotics is definitely an old story and this is especially true for intracellular bacterial infections. The poor intracellular bioavailability of antibiotics reduces the efficency of many treatments and thereby promotes resistances. Therefore, the development of nanodevices coupled with antibiotics that are capable of targeting and releasing the drug into the infected-cells appears to be a promising solution to circumvent these complications. Here, we took advantage of two natural terpenes (farnesyl and geranyl) to design nanodevices for an efficient intracellular delivery of penicillin G. The covalent linkage between the terpene moieties and the antibiotic leads to formation of prodrugs that self-assemble to form nanoparticles with a high drug payload between 55-63%. Futhermore, the addition of an environmentally-sensitive bond between the antibiotic and the terpene led to an efficient antibacterial activity against the intracellular pathogen Staphylococcus aureus with reduced intracellular replication of about 99.9% compared to untreated infected cells. Using HPLC analysis, we demonstrated and quantified the intracellular release of PenG when this sensitive-bond (SB) was present on the prodrug, showing the success of this technology to deliver antibiotics directly into cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.