ArticleFish physiology and biochemistry2016
Ya-fish (Schizothorax prenanti) spexin: identification, tissue distribution and mRNA expression responses to periprandial and fasting.
Article in Fish physiology and biochemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 56 citations in OpenAlex.
- The role of Spexin and Phoenixin-20 in girls during puberty.BMC endocrine disorders · 2026Article
- Emerging roles of spexin in cardiovascular homeostasis.Frontiers in cardiovascular medicine · 2026Review
- Spexin-Mediated Dietary Adaptation inAnimals : an open access journal from MDPI · 2025Article
- Spexin and its receptors in the yellowtail kingfish (Seriola lalandi): identification, expression profiles and reproductive function.Fish physiology and biochemistry · 2024Article
- Immunoexpression of Spexin in Selected Segments of the Bovine (Animals : an open access journal from MDPI · 2023Article
- Spexin in the European sea bass, Dicentrarchus labrax: Characterization, brain distribution, and interaction with Gnrh and Gnih neurons.The Journal of comparative neurology · 2023Article
- Circulating Spexin Is Associated with Body Mass Index and Fat Mass but Not with Physical Activity and Psychological Parameters in Women across a Broad Body Weight Spectrum.Journal of clinical medicine · 2022Article
- Impact of spexin on metabolic diseases and inflammation: An updated minireview.Experimental biology and medicine (Maywood, N.J.) · 2022Review
- Spexin Regulates Hypothalamic Leptin Action on Feeding Behavior.Biomolecules · 2022Article
- New evidence for SPX2 in regulating the brain-pituitary reproductive axis of half-smooth tongue sole (Frontiers in endocrinology · 2022Article
- Spexin and Galanin in Metabolic Functions and Social Behaviors With a Focus on Non-Mammalian Vertebrates.Frontiers in endocrinology · 2022Review
- Article
- Effect of Fasting on the Spexin System in Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
- Functions of galanin, spexin and kisspeptin in metabolism, mood and behaviour.Nature reviews. Endocrinology · 2021Review
- Mouse Spexin: (III) Differential Regulation by Glucose and Insulin in Glandular Stomach and Functional Implication in Feeding Control.Frontiers in endocrinology · 2021Article
- Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level.Frontiers in endocrinology · 2021Article
- Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus.Frontiers in endocrinology · 2021Article
- Identification, tissue distribution, periprandial expression, and anorexigenic effect of spexin in Siberian sturgeon, Acipenser baeri.Fish physiology and biochemistry · 2020Article
- Spexin status in relation to obesity and its related comorbidities: a systematic review.Journal of diabetes and metabolic disorders · 2020Review
- Spexin as an indicator of beneficial effects of exercise in human obesity and diabetes.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spexin (SPX) is a novel peptide which was known for its role in physiological homeostasis. A recent study has confirmed that SPX plays an important role in the feeding regulation. However, the reports about SPX are very limited. In the present study, we characterized the structure, distribution and mRNA expression responses to feeding status of SPX in Ya-fish (Schizothorax prenanti). The full-length cDNA of Ya-fish SPX was 1330 base pairs (bp), which encoded 106 amino acid residues. These residues contained a 31-amino acid signal peptide region and a 14-amino acid mature peptide. The sequence alignment demonstrated that the Ya-fish SPX showed high conservation with other species. Our data revealed that SPX was widely expressed in all test tissues. The highest expression of SPX mRNA was observed in Ya-fish forebrain. Compared with the Ya-fish SPX mRNA expression in the forebrain between the preprandial and postprandial groups, the fed group was prominently increased than unfed groups after a meal, while the unfed group at 1 and 3 h substantially decreased than preprandial groups (P < 0.01). In addition, SPX mRNA expression in forebrain was significantly decreased (P < 0.01) during fasting for a week and sharply increased (P < 0.01) after refeeding on the 7th day, and then return to normal level on the 9th day. These results point toward that SPX mRNA expression is regulated by metabolic status or feeding conditions in Ya-fish.
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