ArticleVirology journal2015
Revisiting the taxonomical classification of Porcine Circovirus type 2 (PCV2): still a real challenge.
Article in Virology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 76 citations in OpenAlex.
- A randomized controlled study on the efficacy of a novel combination vaccine against enzootic pneumonia (Mycoplasma hyopneumoniae) and porcine Circovirus type 2 (PCV2) in the presence of strong maternally derived PCV2 immunity in pigs.BMC veterinary research · 2017Trial
- Epidemiological and genetic variation analysis of emerging porcine circovirus type 3 in Henan Province, 2023-2024.BMC veterinary research · 2026Article
- Beyond labels: current sequencing data do not support standardized porcine circovirus 3 (PCV3) genotypes.BMC veterinary research · 2026Article
- The Decade of Porcine Circovirus Type 2 (PCV2) in Thailand: Phylodynamic and Molecular Epidemiology.Transboundary and emerging diseases · 2025Article
- Epidemiological and genetic variation analysis of emerging porcine circovirus type 2 in Henan Province, 2023.Frontiers in veterinary science · 2025Article
- The single-cell transcriptional landscape of lung cells from PCV2d-infected mice.Frontiers in microbiology · 2025Article
- First detection of PCV4 in swine in the United States: codetection with PCV2 and PCV3 and direct detection within tissues.Scientific reports · 2024Article
- Evidence of Porcine Circovirus Type 2 (PCV2) Genetic Shift from PCV2b to PCV2d Genotype in Sardinia, Italy.Viruses · 2023Article
- Molecular characterization and phylogenetic analysis of porcine circovirus 2 from Kerala, India.Virusdisease · 2023Article
- Porcine circovirus 3 (PCV-3) variability: Is it in the virus or in the classification criteria?Virology journal · 2023Article
- Genotype Shift of Malaysian Porcine Circovirus 2 (PCV2) from PCV2b to PCV2d within a Decade.Animals : an open access journal from MDPI · 2022Article
- Genetic Diversity of Porcine Circovirus Types 2 and 3 in Wild Boar in Italy.Animals : an open access journal from MDPI · 2022Article
- Computational based design and tracking of synthetic variants of Porcine circovirus reveal relations between silent genomic information and viral fitness.Scientific reports · 2021Article
- Discriminating the eight genotypes of the porcine circovirus type 2 with TaqMan-based real-time PCR.Virology journal · 2021Article
- Porcine Circovirus 2 Genotypes, Immunity and Vaccines: Multiple Genotypes but One Single Serotype.Pathogens (Basel, Switzerland) · 2020Review
- Detection and genotyping of Porcine circovirus 2 (PCV-2) and detection of Porcine circovirus 3 (PCV-3) in sera from fattening pigs of different European countries.Transboundary and emerging diseases · 2020Article
- Porcine Circovirus Type 2 Pathogenicity Alters Host's Central Tolerance for Propagation.Pathogens (Basel, Switzerland) · 2020Article
- A Heterologous Viral Protein Scaffold for Chimeric Antigen Design: An Example PCV2 Virus Vaccine Candidate.Viruses · 2020Article
- GenotypingViruses · 2020Article
- Incorporation of a truncated form of flagellin (TFlg) into porcine circovirus type 2 virus-like particles enhances immune responses in mice.BMC veterinary research · 2020Article
Corrections and comments
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Authors and funding
8 authors at 7 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPCV2 has emerged as one of the most devastating viral infections of swine farming, causing a relevant economic impact due to direct losses and control strategies expenses. Epidemiological and experimental studies have evidenced that genetic diversity is potentially affecting the virulence of PVC2. The growing number of PCV2 complete genomes and partial sequences available at GenBank questioned the accepted PCV2 classification.
methodsNine hundred seventy five PCV2 complete genomes and 1,270 ORF2 sequences available from GenBank were subjected to recombination, PASC and phylogenetic analyses and results were used for comparison with previous classification scheme.
resultsThe outcome of these analyses favors the recognition of four genotypes on the basis of ORF2 sequences, namely PCV2a, PCV2b, PCV2c and PCV2d-mPCV2b. To deal with the difficulty of founding an unambiguous classification and accounting the impossibility to define a p-distance cut-off, a set of reference sequences that could be used in further phylogenetic studies for PCV2 genotyping was established. Being aware that extensive phylogenetic analyses are time-consuming and often impracticable during routine diagnostic activity, ORF2 nucleotide positions adequately conserved in the reference sequences were identified and reported to allow a quick genotype differentiation.
conclusionsGlobally, the present work provides an updated scenario of PCV2 genotypes distribution and, based on the limits of the previous classification criteria, proposes new rapid and effective schemes for differentiating the four defined PCV2 genotypes.
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