ArticleJournal of the American Geriatrics Society2015
Multimorbidity and Risk of Mild Cognitive Impairment.
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
116 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Multimorbidity and risk of dementia: A systematic review and meta-analysis of longitudinal cohort studies.The journal of prevention of Alzheimer's disease · 2025Pooled it
- The Potential Contribution of Chronic Pain and Common Chronic Pain Conditions to Subsequent Cognitive Decline, New Onset Cognitive Impairment, and Incident Dementia: A Systematic Review and Conceptual Model for Future Research.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Cardiovascular-kidney-metabolic syndrome stage modifies the efficacy of intensive blood pressure control on cognitive outcomes: A post hoc analysis of SPRINT MIND.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Identifying cognitive impairment in older adults using machine learning on combined fNIRS and motion data during an upper extremity dual task function.Research square · 2026Article
- Chronic disease comorbidity and its impact on healthcare utilization among older adults in China: a cross-sectional and longitudinal analysis.BMC geriatrics · 2026Article
- Discrepancies in loneliness and social isolation predict cognitive impairment through chronic disease burden.Brain, behavior, & immunity - health · 2026Article
- Multimorbidity, health service use, and health insurance by socioeconomic groups in 31 countries: A multi-cohort study.PLoS medicine · 2026Article
- The impact of cardiometabolic multimorbidity on cognitive function in older adults: a review.Frontiers in public health · 2026Review
- Financial burden of older inpatients with multimorbidity in China: a cross-sectional study.Frontiers in public health · 2026Article
- Article
- Cognitive trajectories in older adults and associated mortality and predictors.Social psychiatry and psychiatric epidemiology · 2025Article
- Beyond Somatic Multimorbidity: Longitudinal Effects of Edentulism and Mental Health on Cognition in Older Adults.Journal of the American Medical Directors Association · 2025Article
- Burden of multimorbidity and verbal phonemic fluency in cognitively healthy and mildly impaired older adults: findings from a real-world study.Aging clinical and experimental research · 2025Article
- Beyond "worried well": health care professionals' perspectives on improving subjective cognitive decline care.The Gerontologist · 2025Article
- Multimorbidity in dementia: Current perspectives and future challenges.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Association of multimorbidity and disease clusters with neuroimaging and cognitive outcomes in UK Biobank.The journal of prevention of Alzheimer's disease · 2025Article
- Multiple chronic conditions and polypharmacy in cognitively unimpaired older adults are associated with subsequent cognitive decline: results from the national alzheimer's coordinating center data.Archives of gerontology and geriatrics · 2025Article
- Presence of chronic morbidities alters skeletal muscle health and amino acid kinetics in mild cognitive impairment.Journal of Alzheimer's disease : JAD · 2025Article
- Association of Cardiovascular-Kidney-Metabolic Syndrome With Cognitive Decline and Dementia: The ARIC Study Insights.Journal of the American Heart Association · 2025Article
- Differences in brain function entropy due to cognitive impairment: Application of functional near infrared spectroscopy measures during dual-tasking.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2025Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesTo determine the association between multiple chronic conditions and risk of incident mild cognitive impairment (MCI) and dementia.
designProspective cohort study.
settingOlmsted County, Minnesota.
participantsCognitively normal individuals (N = 2,176) enrolled in the Mayo Clinic Study of Aging (MCSA). MEASUREMENTS: Participants were randomly selected from the community, evaluated by a physician, and underwent neuropsychometric testing at baseline and at 15-month intervals to assess diagnoses of MCI and dementia. Information on International Classification of Diseases, Ninth Revision codes for chronic conditions in the 5 years before enrollment was electronically captured using the Rochester Epidemiology Project medical records linkage system. Multimorbidity was defined as having two or more chronic conditions, and the association between multimorbidity and MCI and dementia was examined using Cox proportional hazards models.
resultsOf 2,176 cognitively normal participants (mean age ± standard deviation 78.5 ± 5.2; 50.6% male), 1,884 (86.6%) had multimorbidity. The risk of MCI or dementia was higher in persons with multimorbidity (hazard ratio (HR) = 1.38, 95% confidence interval (CI) = 1.05-1.82) than in those with one or no chronic condition. The HR was of greater magnitude in persons with four or more conditions (HR = 1.61, 95% CI = 1.21-2.13) than in those with two or three conditions (HR = 1.03, 95% CI = 0.76-1.39) and for men with multimorbidity(HR = 1.53, 95% CI = 1.01-2.31) than for women with multimorbidity (HR = 1.20, 95% CI = 0.83-1.74), compared to those with one or no chronic condition.
conclusionIn older adults, having multiple chronic conditions is associated with greater risk of MCI and dementia. This is consistent with the hypothesis that multiple etiologies may contribute to MCI and late-life dementia. Preventing chronic diseases may be beneficial in delaying or preventing MCI and dementia.
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