ReviewEuropean journal of drug metabolism and pharmacokinetics2016
Pharmacokinetic Herb-Drug Interactions: Insight into Mechanisms and Consequences.
Review in European journal of drug metabolism and pharmacokinetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Impact of CYP3A4 functional variability on ziprasidone metabolism.Frontiers in pharmacology · 2025Article
- Herbal Interactions with Cardiac Medications: A Comprehensive Review of Potential Interactions between Herbal Drugs and Commonly Prescribed Cardiac Medications.Current drug safety · 2025Review
- Cardiovascular Effects of a Glycosylated Flavonoids-Rich Leaf Extract from BrazilianPharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Recent Advancements in Extraction Techniques of Ashwagandha (ACS omega · 2023Review
- Concurrent use of herbal and prescribed medicine by patients in primary health care clinics, South Africa.African journal of primary health care & family medicine · 2023Article
- Herbal medications and natural products for patients with covid-19 and diabetes mellitus: Potentials and challenges.Phytomedicine plus : international journal of phytotherapy and phytopharmacology · 2022Review
- Influence of methylxanthines isolated from Bancha green tea on the pharmacokinetics of sildenafil in rats.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2022Article
- Investigating the Potential Use of Andrographolide as a Coadjuvant in Sickle Cell Anemia Therapy.ACS omega · 2022Article
- A Practical Perspective on the Use of Botanicals During the COVID-19 Pandemic: From Proven to Potential Interactions.Journal of medicinal food · 2022Review
- Integrative Oncology Education: An Emerging Competency for Oncology Providers.Current oncology (Toronto, Ont.) · 2021Article
- Anticancer Potential ofMolecules (Basel, Switzerland) · 2021Article
- Evaluation of Nigerian Medicinal Plants Extract on Human P-glycoprotein and Cytochrome P450 Enzyme Induction: Implications for Herb-drug Interaction.Current drug metabolism · 2021Article
- Coronavirus Disease 2019 and Herbal Therapy: Pertinent Issues Relating to Toxicity and Standardization of Phytopharmaceuticals.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2021Review
- Evaluation of bioactive compounds and antioxidant capacity of edible feijoa (Journal of food science and technology · 2020Article
- Interactions of clinical relevance associated with concurrent administration of prescription drug and food or medicinal plants: a systematic review protocol.Systematic reviews · 2020Article
- Pharmacokinetic Interactions between Cardiovascular Medicines and Plant Products.Cardiovascular therapeutics · 2019Review
- The Effect of Tanreqing Injection on the Pharmacokinetics of Sirolimus in Rats.BioMed research international · 2019Article
- Pharmacokinetics of Chinese medicines: strategies and perspectives.Chinese medicine · 2018Review
- Alterations in Pharmacokinetics of Gemcitabine and Erlotinib by Concurrent Administration of Hyangsayukgunja-Tang, a Gastroprotective Herbal Medicine.Molecules (Basel, Switzerland) · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herbal medicines are currently in high demand, and their popularity is steadily increasing. Because of their perceived effectiveness, fewer side effects and relatively low cost, they are being used for the management of numerous medical conditions. However, they are capable of affecting the pharmacokinetics and pharmacodynamics of coadministered conventional drugs. These interactions are particularly of clinically relevance when metabolizing enzymes and xenobiotic transporters, which are responsible for the fate of many drugs, are induced or inhibited, sometimes resulting in unexpected outcomes. This article discusses the general use of herbal medicines in the management of several ailments, their concurrent use with conventional therapy, mechanisms underlying herb-drug interactions (HDIs) as well as the drawbacks of herbal remedy use. The authors also suggest means of surveillance and safety monitoring of herbal medicines. Contrary to popular belief that "herbal medicines are totally safe," we are of the view that they are capable of causing significant toxic effects and altered pharmaceutical outcomes when coadministered with conventional medicines. Due to the paucity of information as well as sometimes conflicting reports on HDIs, much more research in this field is needed. The authors further suggest the need to standardize and better regulate herbal medicines in order to ensure their safety and efficacy when used alone or in combination with conventional drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.