ArticleWorld journal of surgical oncology2015
Molecular biomarkers screened by next-generation RNA sequencing for non-sentinel lymph node status prediction in breast cancer patients with metastatic sentinel lymph nodes.
Article in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Diagnostic and prognostic values of differentially expressed genes in canine mammary carcinoma: An integrated bioinformatics analysis.PloS one · 2026Article
- Evaluation of Expression and Clinicopathological Relevance of Small Nucleolar RNAs (snoRNAs) in Invasive Breast Cancer.Non-coding RNA · 2025Article
- Identifying Key Genes Involved in Axillary Lymph Node Metastasis in Breast Cancer Using Advanced RNA-Seq Analysis: A Methodological Approach with GLMQL and MAS.International journal of molecular sciences · 2024Article
- Expression of small nucleolar RNA SNORA51 and its clinical significance in hepatocellular carcinoma.Oncology letters · 2024Article
- Single-nucleus RNA sequencing and deep tissue proteomics reveal distinct tumour microenvironment in stage-I and II cervical cancer.Journal of experimental & clinical cancer research : CR · 2023Article
- A nomogram based on genotypic and clinicopathologic factors to predict the non-sentinel lymph node metastasis in Chinese women breast cancer patients.Frontiers in oncology · 2023Article
- Comprehensive analysis of the cancer driver genes in breast cancer demonstrates their roles in cancer prognosis and tumor microenvironment.World journal of surgical oncology · 2021Article
- MicroRNA-638 inhibits the progression of breast cancer through targeting HOXA9 and suppressing Wnt/β-cadherin pathway.World journal of surgical oncology · 2021Article
- IGLL5 is correlated with tumor-infiltrating immune cells in clear cell renal cell carcinoma.FEBS open bio · 2021Article
- Novel Biomarkers Aim at Detecting Metastatic Sentinel Lymph Nodes in Breast CancerIranian biomedical journal · 2020Article
- Identification of genes of prognostic value in the ccRCC microenvironment from TCGA database.Molecular genetics & genomic medicine · 2020Article
- Guide snoRNAs: Drivers or Passengers in Human Disease?Biology · 2018Review
- Molecular patterns of cancer colonisation in lymph nodes of breast cancer patients.Breast cancer research : BCR · 2018Review
- Lymph Nodes in Breast Cancer - What Can We Learn from Translational Research?Breast care (Basel, Switzerland) · 2018Review
- Organotropism: new insights into molecular mechanisms of breast cancer metastasis.NPJ precision oncology · 2018Review
- Comprehensive molecular biomarker identification in breast cancer brain metastases.Journal of translational medicine · 2017Article
- Transcriptome Analysis of Monozygotic Twin Brothers with Childhood Primary Myelofibrosis.Genomics, proteomics & bioinformatics · 2017Article
- snoRNA and piRNA expression levels modified by tobacco use in women with lung adenocarcinoma.PloS one · 2017Article
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Authors and funding
11 authors.
Funding
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Abstract
backgroundNon-sentinel lymph node (NSLN) status prediction with molecular biomarkers may make some sentinel lymph node (SLN) positive breast cancer patients avoid the axillary lymph node dissection, but the available markers remain limited.
methodsSLN positive patients with and without NSLN invasion were selected, and genes differentially expressed or fused in SLN metastasis were screened by next-generation RNA sequencing.
resultsSix candidates (all ER/PR+, HER2-, Ki-67 <20%) with metastatic SLNs selected from 305 patients were equally categorized as NSLN negative and positive. We identified 103 specifically expressed genes in the NSLN negative group and 47 in the NSLN positive group. Among them, FABP1 (negative group) and CYP2A13 (positive group) were the only 2 protein-encoding genes with expression levels in the 8th to 10th deciles. Using a false discovery rate threshold of <0.05, 62 up-regulated genes and 98 down-regulated genes were discovered in the NSLN positive group. Furthermore, 10 gene fusions were identified in this group with the most frequently fused gene being IGLL5.
conclusionsThe biomarkers screened in present study may broaden our understanding of the mechanisms of breast cancer metastasis to the lymph nodes and contribute to the axillary surgery selection for SLN positive patients.
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