ArticleJournal of neurophysiology2015
Normalization in human somatosensory cortex.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 38 citations in OpenAlex.
- Illusory cold desensitizes touch.bioRxiv : the preprint server for biology · 2026Article
- Hierarchical Neural Circuit Theory of Normalization and Inter-areal Communication.bioRxiv : the preprint server for biology · 2025Article
- Pseudo-linear summation explains neural geometry of multi-finger movements in human premotor cortex.Nature communications · 2025Article
- Computational model links normalization to chemoarchitecture in the human visual system.Science advances · 2024Article
- Restoration of natural somatic sensations to the amputees: finding the right combination of neurostimulation methods.Frontiers in neuroscience · 2024Article
- Hello from the other side: Robust contralateral interference in tactile detection.Attention, perception & psychophysics · 2024Article
- Mapping the Integration of Sensory Information across Fingers in Human Sensorimotor Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Aberrant functional connectivity and temporal variability of the dynamic pain connectome in patients with low back related leg pain.Scientific reports · 2022Article
- Divisive normalization unifies disparate response signatures throughout the human visual hierarchy.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- A functional spiking neuronal network for tactile sensing pathway to process edge orientation.Scientific reports · 2021Article
- Differential impact of endogenous and exogenous attention on activity in human visual cortex.Scientific reports · 2020Article
- Disinhibition of Human Primary Somatosensory Cortex After Median Nerve Transection and Reinnervation.Frontiers in human neuroscience · 2020Article
- Neural Coding of Contact Events in Somatosensory Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Cortical Correlates of Attention to Auditory Features.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- High-dimensional representation of texture in somatosensory cortex of primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Inverted Encoding Models of Human Population Response Conflate Noise and Neural Tuning Width.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Functional magnetic resonance imaging (fMRI) was used to measure activity in human somatosensory cortex and to test for cross-digit suppression. Subjects received stimulation (vibration of varying amplitudes) to the right thumb (target) with or without concurrent stimulation of the right middle finger (mask). Subjects were less sensitive to target stimulation (psychophysical detection thresholds were higher) when target and mask digits were stimulated concurrently compared with when the target was stimulated in isolation. fMRI voxels in a region of the left postcentral gyrus each responded when either digit was stimulated. A regression model (called a forward model) was used to separate the fMRI measurements from these voxels into two hypothetical channels, each of which responded selectively to only one of the two digits. For the channel tuned to the target digit, responses in the left postcentral gyrus increased with target stimulus amplitude but were suppressed by concurrent stimulation to the mask digit, evident as a shift in the gain of the response functions. For the channel tuned to the mask digit, a constant baseline response was evoked for all target amplitudes when the mask was absent and responses decreased with increasing target amplitude when the mask was concurrently presented. A computational model based on divisive normalization provided a good fit to the measurements for both mask-absent and target + mask stimulation. We conclude that the normalization model can explain cross-digit suppression in human somatosensory cortex, supporting the hypothesis that normalization is a canonical neural computation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.