ReviewOrthopaedic surgery2015
Role of Curcumin in Common Musculoskeletal Disorders: a Review of Current Laboratory, Translational, and Clinical Data.
Review in Orthopaedic surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 5 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?Frontiers in physiology · 2026Pooled it
- Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism-A Systematic Review.Nutrients · 2022Pooled it
- Efficacy and Safety of Curcumin andFrontiers in immunology · 2022Pooled it
- Efficacy and Safety of Turmeric Extracts for the Treatment of Knee Osteoarthritis: a Systematic Review and Meta-analysis of Randomised Controlled Trials.Current rheumatology reports · 2021Pooled it
- Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.Journal of medicinal food · 2016Pooled it
- Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis.Archives of endocrinology and metabolism · 2018Trial
- Hyaluronic Acid Ultra-Porous Scaffolds Reinforced with Low Quantities of Graphene Oxide: Influence on the Delivery of Curcumin and Bacterial Inhibition.Nanomaterials (Basel, Switzerland) · 2025Article
- An acid-responsive bone-targeting nanoplatform loaded with curcumin balances osteogenic and osteoclastic functions.Regenerative biomaterials · 2025Article
- The Role of Curcumin in Oral Health and Diseases: A Systematic Review.Antioxidants (Basel, Switzerland) · 2024Review
- Alternative Medical Therapy.Indian journal of orthopaedics · 2023Review
- Review
- The Credible Role of Curcumin in Oxidative Stress-Mediated Mitochondrial Dysfunction in Mammals.Biomolecules · 2022Review
- Metabolic Reconfiguration Activates Stemness and Immunomodulation of PDLSCs.International journal of molecular sciences · 2022Article
- Preparation, Physicochemical Assessment and the Antimicrobial Action of Hydroxyapatite-Gelatin/Curcumin Nanofibrous Composites as a Dental Biomaterial.Biomimetics (Basel, Switzerland) · 2021Article
- Cytotoxic, chemosensitizing and radiosensitizing effects of curcumin based on thioredoxin system inhibition in breast cancer cells: 2D vs. 3D cell culture system.Experimental and therapeutic medicine · 2021Article
- Early Osteogenic Differentiation Stimulation of Dental Pulp Stem Cells by Calcitriol and Curcumin.Stem cells international · 2021Article
- Prospective, Multicenter Evaluation of a Polyherbal Supplement alongside Standard-of-Care Treatment for Mild Knee Osteoarthritis.Advances in orthopedics · 2021Article
- Osteogenic Differentiation of Mesenchymal Stem Cells via Curcumin-Containing Nanoscaffolds.Stem cells international · 2021Review
- The Effect of Curcumin on the Differentiation of Mesenchymal Stem Cells into Mesodermal Lineage.Molecules (Basel, Switzerland) · 2019Review
- A biological extract of turmeric (Curcuma longa) modulates response of cartilage explants to lipopolysaccharide.BMC complementary and alternative medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Indian spice turmeric, in which the active and dominant biomolecule is curcumin, has been demonstrated to have significant medicinal properties, including anti-inflammatory and anti-neoplastic effects. This promise is potentially very applicable to musculoskeletal disorders, which are common causes of physician visits worldwide. Research at the laboratory, translational and clinical levels that supports the use of curcumin for various musculoskeletal disorders, such as osteoarthritis, osteoporosis, musculocartilaginous disorders, and sarcoma is here in comprehensively summarized. Though more phase I-III trials are clearly needed, thus far the existing data show that curcumin can indeed potentially be useful in treatment of the hundreds of millions worldwide who are afflicted by these musculoskeletal disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.