ArticleJournal of the American Geriatrics Society2015
Loss of Weight in Obese Older Adults: A Biomarker of Impending Expansion of Multimorbidity?
Article in Journal of the American Geriatrics Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of an 8-Year Intensive Lifestyle Intervention on an Index of Multimorbidity.Journal of the American Geriatrics Society · 2020Trial
- Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments.Aging cell · 2025Article
- Body mass index, waist circumference, hip circumference, abdominal volume index, and cognitive function in older Chinese people: a nationwide study.BMC geriatrics · 2024Article
- Integrated -omics approach reveals persistent DNA damage rewires lipid metabolism and histone hyperacetylation via MYS-1/Tip60.Science advances · 2022Article
- Body mass trajectories and multimorbidity in old age: 12-year results from a population-based study.Clinical nutrition (Edinburgh, Scotland) · 2021Article
- Multimorbidity and functional impairment-bidirectional interplay, synergistic effects and common pathways.Journal of internal medicine · 2019Review
- Central Obesity and Visceral Adipose Tissue Are Not Associated With Incident Atherosclerotic Cardiovascular Disease Events in Older Men.Journal of the American Heart Association · 2018Article
- Gender, nutritional status and disability-free life expectancy among older people in Santiago, Chile.PloS one · 2018Article
- Associations of recent weight loss with health care costs and utilization among older women.PloS one · 2018Article
- Review
- [Obesity in elderly].Wiener medizinische Wochenschrift (1946) · 2016Review
- Aging and Multimorbidity: New Tasks, Priorities, and Frontiers for Integrated Gerontological and Clinical Research.Journal of the American Medical Directors Association · 2015Review
Corrections and comments
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Authors and funding
11 authors at 7 institutions in 2 countries.
Funding
Abstract
objectivesTo determine whether weight loss in older adults may be a marker of impending burden of multimorbidity regardless of initial weight, testing the hypotheses that obesity but not overweight in elderly adults is associated with greater number of diseases than normal weight and that obese older adults who lose weight over time have the greatest burden of multimorbidity.
designLongitudinal cohort study (Invecchiare in Chianti Study).
settingCommunity.
participantsIndividuals aged 60 and older at baseline followed for an average of 4 years (N = 1,025). MEASUREMENTS: Multimorbidity was measured as number of diagnosed diseases. Baseline body mass index (BMI) was categorized as normal weight (<25.0 kg/m(2)), overweight (25.0-29.9 kg/m(2)), and obese (≥30.0 kg/m(2)). Loss of weight was defined as decrease over time in BMI of at least 0.15 kg/m(2) per year. Age, sex, and education were covariates.
resultsBaseline obesity was cross-sectionally associated with high multimorbidity and greater longitudinal increase of multimorbidity than normal weight (P = .005) and overweight (P < .001). Moreover, obese participants who lost weight over follow-up had a significantly greater increase in multimorbidity than other participants, including obese participants who maintained or gained weight over time (P = .005). In nonobese participants, changes in weight had no effect on changes in multimorbidity over time. Sensitivity analyses confirmed that one specific disease did not drive the association and that competing mortality did not bias the association.
conclusionLoss of weight in obese older persons is a strong biomarker of impending expansion of multimorbidity. Older obese individuals who lose weight should receive thoughtful medical attention.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.