ArticleJournal of nanobiotechnology2015
Surface plasmon resonance based on molecularly imprinted nanoparticles for the picomolar detection of the iron regulating hormone Hepcidin-25.
Article in Journal of nanobiotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Towards engineering molecularly imprinted polymer-based sensors: linking design strategies to analytical and operational performance.Analytical and bioanalytical chemistry · 2026Review
- A Tutorial Review on Surface Plasmon Resonance Biosensors: Applications in Biomedicine.ACS bio & med chem Au · 2025Article
- Rapid and Sensitive Detection by Combining Electric Field Effects and Surface Plasmon Resonance: A Theoretical Study.Micromachines · 2024Article
- Comparison of Fluidic and Non-Fluidic Surface Plasmon Resonance Biosensor Variants for Angular and Intensity Modulation Measurements.Sensors (Basel, Switzerland) · 2023Article
- Imprinted Hydrogel Nanoparticles for Protein Biosensing: A Review.ACS sensors · 2023Review
- Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review.Biosensors · 2022Review
- BioMIPs: molecularly imprinted silk fibroin nanoparticles to recognize the iron regulating hormone hepcidin.Mikrochimica acta · 2022Article
- Iron, Copper, and Zinc Homeostasis: Physiology, Physiopathology, and Nanomediated Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Assessing the perfluoroalkyl acid-induced swelling of Förster resonance energy transfer-capable poly(Soft matter · 2021Article
- Molecularly imprinted polymers by epitope imprinting: a journey from molecular interactions to the available bioinformatics resources to scout for epitope templates.Analytical and bioanalytical chemistry · 2021Review
- Gold-silver core-shell nanoparticle-based impedimetric immunosensor for detection of iron homeostasis biomarker hepcidin.Mikrochimica acta · 2020Article
- Molecular Imprinted Polymers Coupled to Photonic Structures in Biosensors: The State of Art.Sensors (Basel, Switzerland) · 2020Review
- The Principle of Nanomaterials Based Surface Plasmon Resonance Biosensors and Its Potential for Dopamine Detection.Molecules (Basel, Switzerland) · 2020Review
- Molecularly Imprinted Polymer Based Sensors for Medical Applications.Sensors (Basel, Switzerland) · 2019Review
- MIRATE: MIps RATional dEsign Science Gateway.Journal of integrative bioinformatics · 2018Article
- Impact of graphene-based nanomaterials (GBNMs) on the structural and functional conformations of hepcidin peptide.Journal of computer-aided molecular design · 2018Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMolecularly imprinted polymer (MIP) technique is a powerful mean to produce tailor made synthetic recognition sites. Here precipitation polymerization was exploited to produce a library of MIP nanoparticles (NPs) targeting the N terminus of the hormone Hepcidin-25, whose serum levels correlate with iron dis-metabolisms and doping. Biotinylated MIP NPs were immobilized to NeutrAvidin™ SPR sensor chip. The response of the MIP NP sensor to Hepcidin-25 was studied.
findingsMorphological analysis showed MIP NPs of 20-50 nm; MIP NP exhibited high affinity and selectivity for the target analyte: low nanomolar Kds for the interaction NP/Hepcidin-25, but none for the NP/non regulative Hepcidin-20. The MIP NP were integrated as recognition element in SPR allowing the detection of Hepcidin-25 in 3 min. Linearity was observed with the logarithm of Hepcidin-25 concentration in the range 7.2-720 pM. LOD was 5 pM. The response for Hepcidin-20 was limited. Hepcidin-25 determination in real serum samples spiked with known analyte concentrations was also attempted.
conclusionThe integration of MIP NP to SPR allowed the determination of Hepcidin-25 at picomolar concentrations in short times outperforming the actual state of art. Optimization is still needed for real sample measurements in view of future clinical applications.
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