ArticleJournal of medical toxicology : official journal of the American College of Medical Toxicology2015
Improvement in Hemodynamics After Methylene Blue Administration in Drug-Induced Vasodilatory Shock: A Case Report.
Article in Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 45 citations in OpenAlex.
- Successful treatment of metformin and rodenticide intoxication with prolonged hemodialysis and methylene blue: A case report.Toxicology reports · 2024Article
- Rescue of Nimodipine-Induced Refractory Vasoplegia With Hydroxocobalamin in Subarachnoid Hemorrhage: A Case Report.Critical care explorations · 2020Article
- Vasopressor-Sparing Action of Methylene Blue in Severe Sepsis and Shock: A Narrative Review.Advances in therapy · 2020Review
- Use of a Porcine Model to Evaluate the Risks and Benefits of Vasopressors in Propranolol Poisoning.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Article
- Development and Feasibility of a Porcine Model of Amlodipine Toxicity.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2020Article
- Hemodynamic improvement using methylene blue after calcium channel blocker overdose.World journal of emergency medicine · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe purpose of this study is to describe a case where methylene blue improved hemodynamics in a poisoned patient. CASE REPORT: This is a single case report where a poisoned patient developed vasodilatory shock following ingestion of atenolol, amlodipine, and valsartan. Shock persisted after multiple therapies including vasopressors, high-dose insulin, hemodialysis, and 20% intravenous fat emulsion. Methylene blue (2 mg/kg IV over 30 min) was administered in the ICU with temporal improvement as measured by pulmonary artery catheter hemodynamic data pre- and post-methylene blue administration. Within 1 h of methylene blue administration, systemic vascular resistance improved (240 dyn s/cm5 increased to 1204 dyn s/cm5), and vasopressor requirements decreased with maintenance of mean arterial pressure 60 mmHg. DISCUSSION: Methylene blue may improve hemodynamics in drug-induced vasodilatory shock and should be considered in critically ill patients poisoned with vasodilatory medications refractory to standard therapies.
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