ArticleScientific reports2015
The substrate matters in the Raman spectroscopy analysis of cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Automated Background Noise Removal from Substrate Materials in Raman Spectra Using Dynamic Time Warping.ACS omega · 2025Article
- Assessment of household settled dust via silicon nanomembrane analysis pipeline (SNAP).Environmental technology & innovation · 2025Article
- SERS of nitro group compounds for sensing of explosives.RSC advances · 2025Article
- Machine Learning-Assisted SERS Reveals the Biochemical Signature of Enhanced Protein Secretion from Surface-Modified Magnetic Nanoparticles.ACS applied materials & interfaces · 2024Article
- Unveiling the efficacy of a bulk Raman spectra-based model in predicting single cell Raman spectra of microorganisms.Heliyon · 2024Article
- Illuminating the Tiny World: A Navigation Guide for Proper Raman Studies on Microorganisms.Molecules (Basel, Switzerland) · 2024Review
- Visualization-enhanced under-oil open microfluidic system for in situ characterization of multi-phase chemical reactions.Nature communications · 2024Article
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- Comparative Study of Sample Carriers for the Identification of Volatile Compounds in Biological Fluids Using Raman Spectroscopy.Molecules (Basel, Switzerland) · 2022Article
- Raman Microscopic Identification of Microorganisms on Metal Surfaces via Support Vector Machines.Microorganisms · 2022Article
- Antibacterial and Antifungal Properties of Silver Nanoparticles-Effect of a Surface-Stabilizing Agent.Biomolecules · 2021Article
- Optimization of High-Density Fe-Au Nano-Arrays for Surface-Enhanced Raman Spectroscopy of Biological Samples.Biosensors · 2021Article
- Development of an inexpensive Raman-compatible substrate for the construction of a microarray screening platform.The Analyst · 2020Article
- Surface enhanced Raman scattering artificial nose for high dimensionality fingerprinting.Nature communications · 2020Article
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- Gold nanoisland substrates for SERS characterization of cultured cells.Biomedical optics express · 2019Article
- Investigation on the Cancer Invasion and Metastasis of Skin Squamous Cell Carcinoma by Raman Spectroscopy.Molecules (Basel, Switzerland) · 2019Article
- FTIR and Raman Spectroscopy-Based Biochemical Profiling Reflects Genomic Diversity of ClinicalInternational journal of molecular sciences · 2019Article
- Mirrored stainless steel substrate provides improved signal for Raman spectroscopy of tissue and cells.Journal of Raman spectroscopy : JRS · 2017Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Raman spectroscopy is a powerful analytical method that allows deposited and/or immobilized cells to be evaluated without complex sample preparation or labeling. However, a main limitation of Raman spectroscopy in cell analysis is the extremely weak Raman intensity that results in low signal to noise ratios. Therefore, it is important to seize any opportunity that increases the intensity of the Raman signal and to understand whether and how the signal enhancement changes with respect to the substrate used. Our experimental results show clear differences in the spectroscopic response from cells on different surfaces. This result is partly due to the difference in spatial distribution of electric field at the substrate/cell interface as shown by numerical simulations. We found that the substrate also changes the spatial location of maximum field enhancement around the cells. Moreover, beyond conventional flat surfaces, we introduce an efficient nanostructured silver substrate that largely enhances the Raman signal intensity from a single yeast cell. This work contributes to the field of vibrational spectroscopy analysis by providing a fresh look at the significance of the substrate for Raman investigations in cell research.
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