ArticleBMC evolutionary biology2015
Increased exposure to acute thermal stress is associated with a non-linear increase in recombination frequency and an independent linear decrease in fitness in Drosophila.
Article in BMC evolutionary biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 40 citations in OpenAlex.
- Influence of geography, seasonality and experimental selection on Chironomus riparius recombination rates.BMC genomics · 2026Article
- Seasonal changes in recombination characteristics in a natural population of Drosophila melanogaster.Heredity · 2021Article
- Effect of Temperature and Maternal Age on Recombination Rate in Cattle.Frontiers in genetics · 2021Article
- The evolutionary advantage of fitness-dependent recombination in diploids: A deterministic mutation-selection balance model.Ecology and evolution · 2020Article
- Effects of silent myocardial ischemia on functional fitness and physical independence in 60-79-year-old adults.Sports medicine and health science · 2019Article
- Linked-read sequencing of gametes allows efficient genome-wide analysis of meiotic recombination.Nature communications · 2019Article
- Variation in Recombination Rate Is Shaped by Domestication and Environmental Conditions in Barley.Molecular biology and evolution · 2019Article
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- Substantial Heritable Variation in Recombination Rate on Multiple Scales in Honeybees and Bumblebees.Genetics · 2019Article
- Wolbachia Infection Associated with Increased Recombination inG3 (Bethesda, Md.) · 2019Article
- ImmunoFISH: Simultaneous Visualisation of Proteins and DNA Sequences Gives Insight Into Meiotic Processes in Nuclei of Grasses.Frontiers in plant science · 2018Article
- Recombination rate plasticity: revealing mechanisms by design.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- What drives the evolution of condition-dependent recombination in diploids? Some insights from simulation modelling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Condition-dependent sex: who does it, when and why?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- The Genetic Architecture of Natural Variation in Recombination Rate in Drosophila melanogaster.PLoS genetics · 2016Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMeiotic recombination rate has long been known to be phenotypically plastic. How plastic recombination evolves and is maintained remains controversial; though a leading model for the evolution of plastic recombination rests on the tenet that organismal fitness and recombination frequency are negatively correlated. Motivated by the mounting evidence that meiotic recombination frequencies increase in response to stress, here we test for a negative correlation between fitness and recombination frequency. Specifically, the fitness-associated recombination model (FAR) predicts that if stress increases meiotic recombination frequency, then increasing exposure to stressful conditions will yield an increasing magnitude of the recombinational response, while concomitantly decreasing fitness.
resultsWe use heat shock as a stressor to test this prediction in Drosophila melanogaster. We find that increased exposure to heat shock conditions is associated with a non-linear increase in meiotic recombination frequency. We also find an independent effect of heat shock on organismal fitness, with fitness decreasing with increased duration of thermal stress.
conclusionsOur results thus support the foundation of the FAR model for the evolution of plastic recombination. Our data also suggest that modulating recombination frequency is one mechanism by which organisms can rapidly respond to environmental cues and confer increased adaptive potential to their offspring.
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