Trial reportJournal of genetic counseling2016
Reproductive Health CHOICES for Young Adults with Sickle Cell Disease or Trait: Randomized Controlled Trial Outcomes over Two Years.
Trial report in Journal of genetic counseling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.The Cochrane database of systematic reviews · 2021Pooled it
- Tailored Parenting Plans of Young Adults With Sickle Cell Disease or Sickle Cell Trait.Computers, informatics, nursing : CIN · 2022Trial
- Randomized clinical trial of computerized PAINRelieveIt® for patients with sickle cell disease: PAINReportIt® and PAINUCope®.Patient education and counseling · 2020Trial
- Perception of young adults with sickle cell disease or sickle cell trait about participation in the CHOICES randomized controlled trial.Journal of advanced nursing · 2016Trial
- Online decision aids for contraceptive choices in women with chronic conditions: A systematic review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Review
- Community-engaged research in psychological interventions for pediatric sickle cell disease: a scoping review.Journal of pediatric psychology · 2025Article
- Article
- CHOICES for sickle cell reproductive health: A protocol of a randomized preconception intervention model for a single gene disorder.PloS one · 2023Article
- Factors associated with young adult engagement with a web-based sickle cell reproductive health intervention.PEC innovation · 2022Article
- Characteristics associated with the perceived likelihood to become parents among young adults with sickle cell disease or sickle cell trait in the USA.Journal of genetic counseling · 2022Article
- Development of an Online Reproductive Health Intervention for Individuals with Sickle Cell Disease or Trait.Women's health reports (New Rochelle, N.Y.) · 2021Article
- Initial psychometric analysis of novel instruments to assess decisional distress and decisional uncertainty in women who have considered using preimplantation genetic testing.Prenatal diagnosis · 2020Article
- Incidence, demographic characteristics, and geographic distribution of sickle cell trait and sickle cell anemia births in Michigan, 1997-2014.Molecular genetics & genomic medicine · 2019Article
- What do people think about genetics? A systematic review.Journal of community genetics · 2019Review
- The current state of sickle cell trait: implications for reproductive and genetic counseling.Hematology. American Society of Hematology. Education Program · 2018Review
- The current state of sickle cell trait: implications for reproductive and genetic counseling.Blood · 2018Review
- Identifying Factors Underlying the Decision for Sickle Cell Carrier Screening Among African Americans Within Middle Reproductive Age.Journal of genetic counseling · 2018Article
- Sickle cell trait knowledge and health literacy in caregivers who receive in-person sickle cell trait education.Molecular genetics & genomic medicine · 2017Article
- Pediatric to Adult Care Transition: Perspectives of Young Adults With Sickle Cell Disease.Journal of pediatric psychology · 2017Article
- Toward understanding family-related characteristics of young adults with sickle-cell disease or sickle-cell trait in the USA.Journal of clinical nursing · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Interventions to assist reproductive health decision-making in populations affected by sickle cell disease (SCD) or trait (SCT) lack proven efficacy over time. Our aim was to compare effects of CHOICES, a Web-based multimedia education program on implementing informed reproductive plans, and usual care education (e-Book) on reproductive knowledge, intention, and behavior over 24 months. We randomized 234 participants with SCD (n = 138) or SCT (n = 96) (age 18-35 years, 35 % male, 94 % African American) to CHOICES and e-Book groups. Participants completed a sickle cell-specific reproductive measure before and four times after the intervention (6, 12, 18 and 24 months). Compared to the e-Book group the CHOICES group had significantly more improvement in knowledge over time (p = .004) but not intention (p = .18) or behavior (p = .69). At baseline, 114 (48.7 %) participants reported having partners who would not put the couple at risk for their children inheriting SCD. Of the 116 (49.6 %) at-risk participants, a higher poroportion of those who were in the CHOICES group chose partners that reduced their risk by the last visit than the e-Book group (p = .04). Study findings provide important insights for designing a national trial of the CHOICES intervention focusing on subjects whose partner status puts them at risk for having a child with SCD.
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