ReviewPediatric nephrology (Berlin, Germany)2016
Health-related quality of life in patients with pediatric onset of end-stage renal disease: state of the art and recommendations for clinical practice.
Review in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 75 citations in OpenAlex.
- A systematic review of symptoms experienced by children and young people with kidney failure.Pediatric nephrology (Berlin, Germany) · 2025Pooled it
- Impact of chronic kidney disease on health-related quality of life in the pediatric population: meta-analysis.Jornal de pediatriaPooled it
- Adaptation and evaluation of PRO-Kid (patient-reported outcome measure for the assessment of symptoms burden in pediatric chronic kidney disease) for children aged 2-7 years.Pediatric nephrology (Berlin, Germany) · 2026Article
- Adequacy of dialysis in children and adolescents: more than just Kt/V.Pediatric nephrology (Berlin, Germany) · 2026Review
- Sociodemographic, health, and oral factors associated with health-related quality of life in children and adolescents with chronic kidney disease: a cross-sectional study.BMC public health · 2026Observational
- The Impact of Exercises and Physical Activity Programs on Paediatric Patients Undergoing Haemodialysis in Africa: A Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Green nephrology: environmentally sustainable kidney care in pediatrics.Pediatric nephrology (Berlin, Germany) · 2026Review
- Pediatric advanced chronic kidney disease as a family challenge: coping and communication in daily life.European journal of pediatrics · 2026Article
- Article
- The impact of socioeconomic determinants of health and resulting health inequalities on children and young people with long-term health conditions in the UK: a scoping review protocol.Systematic reviews · 2025Article
- Haemodiafiltration versus high-flux haemodialysis-a Consensus Statement from the EuDial Working Group of the ERA.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2025Article
- Hemodiafiltration for children with stage 5 chronic kidney disease: technical aspects and outcomes.Pediatric nephrology (Berlin, Germany) · 2024Review
- Mental health and social-emotional functioning in children and adolescents with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2024Review
- Taking care of myself in a different and broken world: self-care practices of adolescents on dialysis.International journal of qualitative studies on health and well-being · 2023Article
- Comparisons of EQ-5D-Y and PedsQL in pediatric patients with mild-to-moderate chronic kidney disease in longitudinal analyses.Health and quality of life outcomes · 2023Article
- Depression and health-related quality of life in adolescents and young adults with childhood-onset end-stage kidney disease: a multicenter study in Japan.Clinical and experimental nephrology · 2023Article
- Caregiver perspectives of dialysis initiation for children with kidney disease: a qualitative study.Pediatric nephrology (Berlin, Germany) · 2022Article
- Validity and reliability of the Dutch version of the PedsQL™ 3.0 End Stage Renal Disease Module in children with chronic kidney disease in Belgium.Pediatric nephrology (Berlin, Germany) · 2022Article
- The Use of Patient-Reported Outcome Measures in Daily Clinical Practice of a Pediatric Nephrology Department.International journal of environmental research and public health · 2022Article
- Perspectives on life participation by young adults with chronic kidney disease: an interview study.BMJ open · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Health-related quality of life (HRQoL) is increasingly recognized as a key outcome in both clinical and research settings in the pediatric population with end-stage renal disease (ESRD). This review aims to: (1) summarize the current knowledge on HRQoL and socioprofessional outcomes and (2) provide strategies for incorporation of HRQoL assessment into clinical practice. Studies report that pediatric patients with ESRD have significantly lower HRQoL scores compared with children with other chronic diseases. Patients treated by dialysis are at particularly high risk for impaired HRQoL. Furthermore, patients more often have impaired neurocognitive functioning and lower academic achievement. Important determinants of impaired HRQoL include medical factors (i.e., receiving dialysis, disabling comorbidities, cosmetic side effects, stunted growth), sociodemographic factors (i.e., female gender, non-Western background) and psychosocial factors (i.e., noneffective coping strategies). Contrary to the situation in childhood, adult survivors of pediatric ESRD report a normal mental HRQoL. Despite this subjective feeling of well-being, these patients have on average experienced significantly more difficulties in completing their education, developing intimate relationships, and securing employment. Several medical and psychosocial strategies may potentially improve HRQoL in children with ESRD. Regular assessment of HRQoL and neurocognitive functioning in order to identify areas in which therapies and interventions may be required should be part of standard clinical care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.