ArticleTranslational oncology2015
Quantification of Regional Breast Density in Four Quadrants Using 3D MRI-A Pilot Study.
Article in Translational oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Quantitative Study on the Breast Density and the Volume of the Mammary Gland According to the Patient's Age and Breast Quadrant.Diagnostics (Basel, Switzerland) · 2023Article
- Automatic and fast segmentation of breast region-of-interest (ROI) and density in MRIs.Heliyon · 2018Article
- 3D MRI for Quantitative Analysis of Quadrant Percent Breast Density: Correlation with Quadrant Location of Breast Cancer.Academic radiology · 2017Article
- Evaluation of the association between quantitative mammographic density and breast cancer occurred in different quadrants.BMC cancer · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeThis study presented a three-dimensional magnetic resonance (MR)-based method to separate a breast into four quadrants for quantitative measurements of the quadrant breast volume (BV) and density.
methodsBreast MR images from 58 healthy women were studied. The breast and the fibroglandular tissue were segmented by using a computer-based algorithm. A breast was divided into four quadrants using two perpendicular planes intersecting at the nipple or the nipple-centroid line. After the separation, the BV, the fibroglandular tissue volume, and the percent density (PD) were calculated. The symmetry of the quadrant BV in the left and right breasts separated by using the nipple alone, or the nipple-centroid line, was compared.
resultsThe quadrant separation made on the basis of the nipple-centroid line showed closer BVs in four quadrants than using the nipple alone. The correlation and agreement for the BV in corresponding quadrants of the left and the right breasts were improved after the nipple-centroid reorientation. Among the four quadrants, PD was the highest in the lower outer and the lowest in the upper outer (significant than the other three) quadrants (P < .05).
conclusionsWe presented a quantitative method to divide a breast into four quadrants. The reorientation based on the nipple-centroid line improved the left to right quadrant symmetry, and this may provide a better standardized method to measure quantitative quadrant density. The cancer occurrence rates are known to vary in different sites of a breast, and our method may provide a tool for investigating its association with the quantitative breast density.
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Registered trials
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