ReviewProgress in molecular biology and translational science2015
Scleral Mechanisms Underlying Ocular Growth and Myopia.
Review in Progress in molecular biology and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of repeated low-level red light therapy on myopia progression in children: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Clinical efficacy of 0.01% atropine in retarding the progression of myopia in children.International ophthalmology · 2021Trial
- Comparison of Corneal Biomechanical Properties among Axial Myopic, Nonaxial Myopic, and Nonmyopic Eyes.BioMed research international · 2020Trial
- Cross-tissue dual-omics analysis reveals molecular programs linked to myopia susceptibility and progression.Life science alliance · 2026Article
- [Research progress and applications of biologically derived materials in scleral reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Review
- Relationship Between Scheimpflug-Based Ocular Biomechanics and Myopia Progression in Adolescents.Bioengineering (Basel, Switzerland) · 2026Article
- Changes in Ocular Biomechanics During Adolescence and Its Relationship with Lifestyle and Myopic Progression: The Oporto Myopia Study.Bioengineering (Basel, Switzerland) · 2026Article
- Influence of High Myopia on Outcomes of iStent Inject W Implantation Combined with Cataract Surgery up to 24 Months of Follow-Up.Journal of clinical medicine · 2026Article
- A transpupillary approach for crosslinking Guinea pig sclera using WST11 and near-infrared light.Scientific reports · 2026Article
- Degradable Suture-Free Scaffold to Induce Therapeutic Ridge Formation and to Control Eye Elongation: A Potential Treatment for Pathological Myopia.Translational vision science & technology · 2026Article
- Relationship Between Lifestyle During School Years, Ocular Biomechanics and Refractive Status in Adult Myopes.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Efficacy of posterior scleral reinforcement in the management of myopic traction maculopathy: a single-arm retrospective study.BMC ophthalmology · 2025Article
- IMI-Interventions for Controlling Myopia Onset and Progression 2025.Investigative ophthalmology & visual science · 2025Review
- Myopia: a review of current concepts, association with nonophthalmological conditions, and treatment strategy in children and adolescents.Clinical and experimental pediatrics · 2025Article
- A Personal Scientific Journey in Ophthalmology: Twenty-Five Years of Translating Research into Novel Therapies.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Single-Cell RNA Sequencing of Rabbit Sclera at Different Developmental Stages: Unveiling Scleral Cells Atlas and the Heterogeneity of Fibroblasts.Investigative ophthalmology & visual science · 2025Article
- Is central vision (and a fovea) needed for emmetropisation?Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2025Article
- Scleral ultrastructure in young rhesus monkeys: A stereological approach.Vision research · 2025Article
- Transcriptomic and proteomic analyses of sclera in lens-induced myopic guinea pigs.BMC genomics · 2025Article
- Corneal biomechanical properties in myopic anisometropia measured by corneal visualization scheimpflug technology.American journal of translational research · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
In the regulation of ocular growth, scleral events critically determine eye size and thus the refractive status of the eye. Increased scleral matrix remodeling can lead to exaggerated eye growth causing myopia and additionally increased risk of ocular pathological complications. Thus, therapies targeting these changes in sclera hold potential to limit such complications since sclera represents a relatively safe and accessible drug target. Understanding the scleral molecular mechanisms underlying ocular growth is essential to identifying plausible therapeutic targets in the sclera. This section provides a brief update on molecular studies that pertain to the sclera in the context of ocular growth regulation and myopia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.