Evidence map›Paper›PMID 26310156›Full record

ReviewProgress in molecular biology and translational science2015

Molecular Genetics of Cataract.

Alan Shiels, J Fielding Hejtmancik

Abstract readReview
In one paragraph

Review in Progress in molecular biology and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

  1. Article
  2. Human Crystallin Variation and Cataract.Investigative ophthalmology & visual science · 2026
    Review
  3. Article
  4. Candidate Genes for Non-Syndromic Pediatric Cataracts.Clinical ophthalmology (Auckland, N.Z.) · 2026
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. NovelInternational journal of molecular sciences · 2023
    Article
  12. Mutational spectrum in a Chinese cohort with congenital cataracts.Molecular genetics & genomic medicine · 2023
    Article
  13. Review
  14. Article
  15. Article
  16. A Novel Mutation inOphthalmology science · 2022
    Article
  17. Article
  18. Article
  19. Case Report: AFrontiers in genetics · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Alan ShielsDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: Shiels@vision.wustl.edu.
J Fielding HejtmancikOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.

Funding

WASHINGTON UNIVERSITY CENTER VISION RESEARCHP30EY002687 · NEI · WASHINGTON UNIVERSITY · PI Philip Raymond Williams · 1985 to 2026
$18.4M
Clinical/molecular Studies In Families With Congenital Or Hereditary CataractsZIAEY000281 · NEI · NATIONAL EYE INSTITUTE · PI HEJTMANCIK, JAMES F. · 2009 to 2025
$18.1M
HUMAN LENS CONNEXIN GENES IN HEREDITARY CATARACTR01EY012284 · NEI · WASHINGTON UNIVERSITY · PI SHIELS, ALAN · 1998 to 2014
$5.4M
EPH-RECEPTOR SIGNALING IN LENS DEVELOPMENT AND AGINGR01EY023549 · NEI · WASHINGTON UNIVERSITY · PI SHIELS, ALAN · 2013 to 2017
$1.7M
NEI NIH HHS EY012284NEI NIH HHS EY02687NEI NIH HHS P30 EY002687NEI NIH HHS R01 EY012284NEI NIH HHS R01 EY023549
6 · The paper itself

Abstract

Lens opacities or cataract(s) represent a universally important cause of visual impairment and blindness. Typically, cataract is acquired with aging as a complex disorder involving environmental and genetic risk factors. Cataract may also be inherited with an early onset either in association with other ocular and/or systemic abnormalities or as an isolated lens phenotype. Here we briefly review recent advances in gene discovery for inherited and age-related forms of cataract that are providing new insights into lens development and aging.

Indexed as

AgingCataractCrystallinsGenetic Association StudiesHumansInheritance PatternsCrystallinsAge-relatedCataractGenesInherited

Identifiers

PMID26310156
PMCPMC5656277

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.