Evidence map›Paper›PMID 26310153›Full record

ReviewProgress in molecular biology and translational science2015

Overview of the Lens.

J Fielding Hejtmancik, Alan Shiels

Abstract readReview
In one paragraph

Review in Progress in molecular biology and translational science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Review
  2. Preventing Age-Related Nuclear Cataract Development - Is Cholesterol the Key?Investigative ophthalmology & visual science · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Cellular Senescence in Health, Disease, and Lens Aging.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Role of Primary Cilia in the Eye.Advances in experimental medicine and biology · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. Toward Tunable Protein-Driven Hydrogel Lens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

J Fielding HejtmancikOphthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Alan ShielsDepartment of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: Shiels@vision.wustl.edu.

Funding

Clinical/molecular Studies In Families With Congenital Or Hereditary CataractsZIAEY000281 · NEI · NATIONAL EYE INSTITUTE · PI HEJTMANCIK, JAMES F. · 2009 to 2025
$18.1M
HUMAN LENS CONNEXIN GENES IN HEREDITARY CATARACTR01EY012284 · NEI · WASHINGTON UNIVERSITY · PI SHIELS, ALAN · 1998 to 2014
$5.4M
EPH-RECEPTOR SIGNALING IN LENS DEVELOPMENT AND AGINGR01EY023549 · NEI · WASHINGTON UNIVERSITY · PI SHIELS, ALAN · 2013 to 2017
$1.7M
NEI NIH HHS R01 EY012284NEI NIH HHS R01 EY023549
6 · The paper itself

Abstract

In order to accomplish its function of transmitting and focusing light, the crystalline lens of the vertebrate eye has evolved a unique cellular structure and protein complement. These distinct adaptations have provided a rich source of scientific discovery ranging from biochemistry and genetics to optics and physics. In addition, because of these adaptations, lens cells persist for the lifetime of an organism, providing an excellent model of the aging process. The chapters dealing with the lens will demonstrate how the different aspects of lens biology and biochemistry combine in this singular refractive organ to accomplish its critical role in the visual system.

Indexed as

AgingAnimalsHumansLens, CrystallineBiochemistryCell biologyDevelopmentGeneticsLens

Identifiers

PMID26310153
PMCPMC5656279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.