Evidence map›Paper›PMID 26310109›Full record

ReviewCurrent opinion in neurobiology2015

Cross-modal synaptic plasticity in adult primary sensory cortices.

Hey-Kyoung Lee, Jessica L Whitt

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 98 citations in OpenAlex.

  1. Article
  2. Excitatory and inhibitory networks diverge following early blindness.Cerebral cortex (New York, N.Y. : 1991) · 2026
    Article
  3. Article
  4. Aging in the Primary Auditory Cortex.Journal of the Association for Research in Otolaryngology : JARO · 2026
    Review
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  19. Review
  20. Visual Deprivation Selectively Reduces Thalamic Reticular Nucleus-Mediated Inhibition of the Auditory Thalamus in Adults.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hey-Kyoung LeeSolomon H. Snyder Department of Neuroscience, Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, United States. Electronic address: heykyounglee@jhu.edu.
Jessica L WhittSolomon H. Snyder Department of Neuroscience, Zanvyl-Krieger Mind/Brain Institute, Johns Hopkins University, Baltimore, MD 21218, United States.
Allen Institute for Brain Science · USJohns Hopkins University · US

Funding

Global Synpatic Plasticity Mechanisms in Visual CortexR01EY014882 · NEI · UNIV OF MARYLAND, COLLEGE PARK · PI Hey-Kyoung Lee · 2004 to 2026
$7.9M
Cross-modal regulation of auditory cortex functionR01EY022720 · NEI · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O, LEE, HEY-KYOUNG · 2013 to 2017
$2.1M
NEI NIH HHS R01 EY014882NEI NIH HHS R01-EY014882NEI NIH HHS R01 EY022720NEI NIH HHS R01-EY022720
6 · The paper itself

Abstract

Sensory loss leads to widespread adaptation of brain circuits to allow an organism to navigate its environment with its remaining senses, which is broadly referred to as cross-modal plasticity. Such adaptation can be observed even in the primary sensory cortices, and falls into two distinct categories: recruitment of the deprived sensory cortex for processing the remaining senses, which we term 'cross-modal recruitment', and experience-dependent refinement of the spared sensory cortices referred to as 'compensatory plasticity.' Here we will review recent studies demonstrating that cortical adaptation to sensory loss involves LTP/LTD and homeostatic synaptic plasticity. Cross-modal synaptic plasticity is observed in adults, hence cross-modal sensory deprivation may be an effective way to promote plasticity in adult primary sensory cortices.

Indexed as

AdultAnimalsHumansNeuronal PlasticitySensorimotor CortexSensory Deprivation

Identifiers

PMID26310109
PMCPMC4641772
OpenAlexW1184050146

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.