ArticleBiomaterials2015
Topographical effects on fiber-mediated microRNA delivery to control oligodendroglial precursor cells development.
Article in Biomaterials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Recent progress in the manipulation of biochemical and biophysical cues for engineering functional tissues.Bioengineering & translational medicine · 2023Review
- Electrospun-Fibrous-Architecture-Mediated Non-Viral Gene Therapy Drug Delivery in Regenerative Medicine.Polymers · 2022Review
- miR-182-5p Regulates Nogo-A Expression and Promotes Neurite Outgrowth of Hippocampal Neurons In Vitro.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Designing electrospun fiber platforms for efficient delivery of genetic material and genome editing tools.Advanced drug delivery reviews · 2022Review
- Nanotechnology-Assisted RNA Delivery: From Nucleic Acid Therapeutics to COVID-19 Vaccines.Small methods · 2021Review
- Mechanotransduction assays for neural regeneration strategies: A focus on glial cells.APL bioengineering · 2021Review
- Scaffold-Based Delivery of CRISPR/Cas9 Ribonucleoproteins for Genome Editing.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Electrospun Fiber Scaffolds for Engineering Glial Cell Behavior to Promote Neural Regeneration.Bioengineering (Basel, Switzerland) · 2020Review
- Hydrogel-Based Localized Nonviral Gene Delivery in Regenerative Medicine Approaches-An Overview.Pharmaceutics · 2020Review
- Maneuvering the Migration and Differentiation of Stem Cells with Electrospun Nanofibers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Review
- Effects of miR-219/miR-338 on microglia and astrocyte behaviors and astrocyte-oligodendrocyte precursor cell interactions.Neural regeneration research · 2020Article
- Mechanical regulation of oligodendrocyte biology.Neuroscience letters · 2020Review
- Mechanosensitivity of Human Oligodendrocytes.Frontiers in cellular neuroscience · 2020Article
- Biomimicking Fiber Scaffold as an Effective In Vitro and In Vivo MicroRNA Screening Platform for Directing Tissue Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination.Molecular therapy : the journal of the American Society of Gene Therapy · 2019Article
- The role of oligodendrocytes and their progenitors on neural interface technology: A novel perspective on tissue regeneration and repair.Biomaterials · 2018Review
- MicroRNA-219 alleviates glutamate-induced neurotoxicity in cultured hippocampal neurons by targeting calmodulin-dependent protein kinase II gamma.Neural regeneration research · 2018Article
- Human mesenchymal stem cell basal membrane bending on gratings is dependent on both grating width and curvature.Scientific reports · 2018Article
- Models for Studying Myelination, Demyelination and Remyelination.Neuromolecular medicine · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Effective remyelination in the central nervous system (CNS) facilitates the reversal of disability in patients with demyelinating diseases such as multiple sclerosis. Unfortunately until now, effective strategies of controlling oligodendrocyte (OL) differentiation and maturation remain limited. It is well known that topographical and biochemical signals play crucial roles in modulating cell fate commitment. Therefore, in this study, we explored the combined effects of scaffold topography and sustained gene silencing on oligodendroglial precursor cell (OPC) development. Specifically, microRNAs (miRs) were incorporated onto electrospun polycaprolactone (PCL) fiber scaffolds with different fiber diameters and orientations. Regardless of fiber diameter and orientation, efficient knockdown of differentiation inhibitory factors were achieved by either topography alone (up to 70%) or fibers integrated with miR-219 and miR-338 (up to 80%, p < 0.05). Small fiber promoted OPC differentiation by inducing more RIP(+) cells (p < 0.05) while large fiber promoted OL maturation by inducing more MBP(+) cells (p < 0.05). Random fiber enhanced more RIP(+) cells than aligned fibers (p < 0.05), regardless of fiber diameter. Upon miR-219/miR-338 incorporation, 2 μm aligned fibers supported the most MBP(+) cells (∼17%). These findings indicated that the coupling of substrate topographic cues with efficient gene silencing by sustained microRNA delivery is a promising way for directing OPC maturation in neural tissue engineering and controlling remyelination in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.