Evidence map›Paper›PMID 26309805›Full record

ArticleBioResearch open access2015

Biomodification of PCL Scaffolds with Matrigel, HA, and SR1 Enhances De Novo Ectopic Bone Marrow Formation Induced by rhBMP-2.

Wenjing Bao, Mei Gao, Yanyan Cheng, Hyun Jae Lee, Qinghao Zhang, Susan Hemingway, Zhibo Luo, Andrzej Krol, Guanlin Yang, Jing An

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioResearch open access, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Wenjing BaoDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York. ; Cancer Research Institute, SUNY Upstate Medical University , Syracuse, New York. ; Department of Medicine, Liaoning University of Traditional Chinese Medicine , Shenyang, China .
Mei GaoDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York. ; Cancer Research Institute, SUNY Upstate Medical University , Syracuse, New York.
Yanyan ChengDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York. ; Cancer Research Institute, SUNY Upstate Medical University , Syracuse, New York. ; Department of Medicine, Liaoning University of Traditional Chinese Medicine , Shenyang, China .
Hyun Jae LeeDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York.
Qinghao ZhangDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York. ; Cancer Research Institute, SUNY Upstate Medical University , Syracuse, New York.
Susan HemingwayDepartment of Radiology, SUNY Upstate Medical University , Syracuse, New York.
Zhibo LuoDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York. ; Cancer Research Institute, SUNY Upstate Medical University , Syracuse, New York. ; Department of Medicine, Liaoning University of Traditional Chinese Medicine , Shenyang, China .
Andrzej KrolDepartment of Radiology, SUNY Upstate Medical University , Syracuse, New York.
Guanlin YangDepartment of Medicine, Liaoning University of Traditional Chinese Medicine , Shenyang, China .
Jing AnDepartment of Pharmacology, SUNY Upstate Medical University , Syracuse, New York. ; Cancer Research Institute, SUNY Upstate Medical University , Syracuse, New York.
SUNY Upstate Medical University · USLiaoning University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The de novo formation of ectopic bone marrow was induced using 1.2-mm-thin polycaprolactone (PCL) scaffolds biomodified with several different biomaterials. In vivo investigations of de novo bone and bone marrow formation indicated that subcutaneous implantation of PCL scaffolds coated with recombinant human bone morphogenetic protein-2 (rhBMP-2) plus Matrigel, hydroxyapatite (HA), or StemRegenin 1 (SR1) improved formation of bone and hematopoietic bone marrow as determined by microcomputed tomography, and histological and hematopoietic characterizations. Our study provides evidence that thin PCL scaffolds biomodified with Matrigel, HA, and SR1 mimic the environments of real bone and bone marrow, thereby enhancing the de novo ectopic bone marrow formation induced by rhBMP-2. This ectopic bone marrow model will serve as a unique and essential tool for basic research and for clinical applications of postnatal tissue engineering and organ regeneration.

Indexed as

de novo bone marrow formationMatrigelPCL scaffoldsrhBMP-2

Identifiers

PMID26309805
PMCPMC4497713
OpenAlexW1480771179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.