Evidence map›Paper›PMID 26309768›Full record

ArticleBiomedical optics express2015

MEMS-based multiphoton endomicroscope for repetitive imaging of mouse colon.

Xiyu Duan, Haijun Li, Zhen Qiu, Bishnu P Joshi, Asha Pant, Arlene Smith, Katsuo Kurabayashi, Kenn R Oldham, Thomas D Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. In Vivo Microendoscopy in the Near-Infrared II Window.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Motion Estimation for a Compact Electrostatic Microscanner via Shared Driving and Sensing Electrodes in Endomicroscopy.IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division · 2020
    Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Functional endoscopy techniques for tracking stem cell fate.Quantitative imaging in medicine and surgery · 2019
    Review
  11. MEMS-in-the-lens 3D beam scanner forProceedings of SPIE--the International Society for Optical Engineering · 2019
    Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Multi-photon vertical cross-sectional imaging with a dynamically-balanced thin-film PZT z-axis microactuator.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2017
    Article
  17. Review
  18. Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiyu DuanDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Haijun LiDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Zhen QiuDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Bishnu P JoshiDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Asha PantDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Arlene SmithDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.
Katsuo KurabayashiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Electrical Engineering, University of Michigan, Ann Arbor, MI, USA.
Kenn R OldhamDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.
Thomas D WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA ; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, USA ; Department of Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA.

Funding

Small Animal Imaging CoreP50CA093990 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ROSS, BRIAN D. · 2002 to 2012
$19.0M
Validation & Pathology CoreU54CA163059 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RUBENSTEIN, JOEL H, WANG, THOMAS D · 2011 to 2022
$12.1M
Targeted Multi-Spectral Dual Axes Confocal Imaging of In Vivo Molecular ExpressioR01CA142750 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KURABAYASHI, KATSUO, LUKER, GARY D · 2010 to 2014
$2.4M
Multi-Photon endomicroscope for real-time in vivo vertical sectioningR01EB020644 · NIBIB · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OLDHAM, KENN R · 2015 to 2018
$1.3M
Olympus FV1000-MPE Confocal & Multi-Photon Imaging SystemS10RR028819 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUKER, GARY D · 2010 to 2010
$940k
NCI NIH HHS P50 CA093990NCI NIH HHS R01 CA142750NCI NIH HHS U54 CA163059NCRR NIH HHS S10 RR028819NIBIB NIH HHS R01 EB020644
6 · The paper itself

Abstract

We demonstrate a handheld multiphoton endomicroscope with 3.4 mm distal diameter that can repetitively image mouse colon in vivo. A 2D resonant MEMS mirror was developed to perform beam scanning in a Lissajous pattern. The instrument has an effective numerical aperture of 0.63, lateral and axial resolution of 2.03 and 9.02 μm, respectively, working distance of 60 μm, and image field-of-view of 300 × 300 μm(2). Hoechst was injected intravenously in mice to stain cell nuclei. We were able to collect histology-like images in vivo at 5 frames/sec, and distinguish between normal and pre-malignant colonic epithelium.

Indexed as

(060.2350) Fiber optics imaging(110.0110) Imaging systems(170.0170) Medical optics and biotechnology(170.2150) Endoscopic imaging(190.4180) Multiphoton processes

Identifiers

PMID26309768
PMCPMC4541532

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.