ArticleBiomedical optics express2015
High-speed multi-exposure laser speckle contrast imaging with a single-photon counting camera.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Time-resolved laser speckle contrast imaging (TR-LSCI) of cerebral blood flow response to intracranial pressure elevation.Journal of biomedical optics · 2026Article
- Characterization of a fiber-coupled SPAD camera system for deep-tissue blood-flow measurement using diffuse correlation spectroscopy.Biomedical optics express · 2026Article
- Time-Resolved Laser Speckle Contrast Imaging (TR-LSCI) of Cerebral Blood Flow Response to Intracranial Pressure Elevation.bioRxiv : the preprint server for biology · 2026Article
- Noninvasive Bedside Approaches for Assessing Microvascular Dysfunction.Journal of vascular research · 2025Review
- Coagulation depth estimation using a line scanner for depth-resolved laser speckle contrast imaging.Biomedical optics express · 2024Article
- Dynamic light scattering and laser speckle contrast imaging of the brain: theory of the spatial and temporal statistics of speckle pattern evolution.Biomedical optics express · 2024Article
- Wide-field intensity fluctuation imaging.Biomedical optics express · 2024Article
- Validation of the Openwater wearable optical system: cerebral hemodynamic monitoring during a breath-hold maneuver.Neurophotonics · 2024Article
- Non-Invasive Continuous Optical Monitoring of Cerebral Blood Flow after Traumatic Brain Injury in Mice Using Fiber Camera-Based Speckle Contrast Optical Spectroscopy.Brain sciences · 2023Article
- Measurements of slow tissue dynamics with short-separation speckle contrast optical spectroscopy.Biomedical optics express · 2023Article
- Multiexposure laser speckle contrast analysis system calibration limited by perfusion-dependent scattering on the skin.Journal of biomedical optics · 2023Article
- Wide-field Intensity Fluctuation Imaging.bioRxiv : the preprint server for biology · 2023Article
- Speed-resolved perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning.Journal of biomedical optics · 2023Article
- All fiber-based illumination system for multi-exposure speckle imaging.Biomedical optics express · 2023Article
- Non-invasive low-cost deep tissue blood flow measurement with integrated Diffuse Speckle Contrast Spectroscopy.Frontiers in neuroergonomics · 2023Article
- Laser speckle simulation tool based on stochastic differential equations for bio imaging applications.Biomedical optics express · 2022Article
- Time resolved speckle contrast optical spectroscopy at quasi-null source-detector separation for non-invasive measurement of microvascular blood flow.Biomedical optics express · 2021Article
- Real-time video-rate perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning.Journal of biomedical optics · 2020Article
- Recovery of the diffuse correlation spectroscopy data-type from speckle contrast measurements: towards low-cost, deep-tissue blood flow measurements.Biomedical optics express · 2019Article
- High-density speckle contrast optical tomography of cerebral blood flow response to functional stimuli in the rodent brain.Neurophotonics · 2019Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Laser speckle contrast imaging (LSCI) has emerged as a valuable tool for cerebral blood flow (CBF) imaging. We present a multi-exposure laser speckle imaging (MESI) method which uses a high-frame rate acquisition with a negligible inter-frame dead time to mimic multiple exposures in a single-shot acquisition series. Our approach takes advantage of the noise-free readout and high-sensitivity of a complementary metal-oxide-semiconductor (CMOS) single-photon avalanche diode (SPAD) array to provide real-time speckle contrast measurement with high temporal resolution and accuracy. To demonstrate its feasibility, we provide comparisons between in vivo measurements with both the standard and the new approach performed on a mouse brain, in identical conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.