ArticleBiomedical optics express2015
Measuring oxygen saturation in retinal and choroidal circulations in rats using visible light optical coherence tomography angiography.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis.Journal of biomedical optics · 2022Pooled it
- Tartrazine-enhanced visible-light OCT for deep-tissue imaging.Biomedical optics express · 2026Article
- Blood flow analysis of retinal neovascularisations in a VLDLR mouse model using contrast-enhanced optical coherence tomography.Biomedical optics express · 2026Article
- Assessing and monitoring abnormal retinal blood circulation for early detection of pre-structural damage and enhanced diabetic retinopathy staging using non-invasive, high-resolution biophotonic imaging technology.Eye (London, England) · 2025Review
- Visible Light Optical Coherence Tomography: Technology and Biomedical Applications.Bioengineering (Basel, Switzerland) · 2025Review
- Visible light optical coherence tomography for assessing retinal structure and function in diseased mouse models.Biomedical optics express · 2025Article
- Visible-light optical coherence tomography and its applications.Neurophotonics · 2025Review
- Fusing multispectral information for retinal layer segmentation.NPJ digital medicine · 2025Article
- Variations in Retinal Oxygen Saturation in a Diverse Healthy Population.Clinical optometry · 2024Article
- Sensitivity of visible range multi-wavelength algorithms for retinal tissue oximetry to acquisition parameters.Biomedical optics express · 2023Article
- Multiple forward scattering reduces the measured scattering coefficient of whole blood in visible-light optical coherence tomography.Biomedical optics express · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Global and Regional Damages in Retinal Ganglion Cell Axon Bundles Monitored Non-Invasively by Visible-Light Optical Coherence Tomography Fibergraphy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Functional and structural ophthalmic imaging using noncontact multimodal photoacoustic remote sensing microscopy and optical coherence tomography.Scientific reports · 2021Article
- Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography.Scientific reports · 2021Article
- Advances in Retinal Oximetry.Translational vision science & technology · 2021Review
- Generating large field of view en-face projection images from intra-acquisition motion compensated volumetric optical coherence tomography data.Biomedical optics express · 2020Article
- Quantification of total haemoglobin concentrations in human whole blood by spectroscopic visible-light optical coherence tomography.Scientific reports · 2019Article
- Monitoring retinal responses to acute intraocular pressure elevation in rats with visible light optical coherence tomography.Neurophotonics · 2019Article
- Quantitative quality-control metrics forBiomedical optics express · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Visible light optical coherence tomography (vis-OCT) has demonstrated its capability of measuring vascular oxygen saturation (sO2) in vivo. Enhanced by OCT angiography, the signal from microvasculature can be further isolated and directly used for sO2 extraction. In this work, we extended the theoretical formulation for OCT angiography-based oximetry by incorporating the contribution from motion contrast enhancement. We presented a new method to eliminate the associated confounding variables due to blood flow. First, we performed in vitro experiments to verify our theory, showing a stable spectral derivative within the selected wavelength bands for sO2 extraction. Then, we tested our method in vivo to measure retinal sO2 in rats inhaling different gas mixtures: normal air, 5% CO2, pure O2, and 10% O2. Absolute sO2 values in major arterioles and venules in the retinal circulation can be accurately measured. In addition, we demonstrated the relative changes of sO2 can be measured non-invasively from choriocapillaris immediately underneath the retinal pigmented epithelium (RPE) in rodents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.