ArticleBiomedical optics express2015
Translational label-free nonlinear imaging biomarkers to classify the human corneal microstructure.
Article in Biomedical optics express, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Characterization of Collagen Fiber Organization in Breast Cancer via Model-Free Multiscale pSHG Image Analysis.Annals of biomedical engineering · 2026Article
- Quantitative Characterization of Corneal Collagen Architecture Using Intensity Gradient Modeling and Gaussian PDF Fitting.Diagnostics (Basel, Switzerland) · 2025Article
- Widefield polarization-resolved second harmonic generation imaging of entire thyroid nodule sections for the detection of capsular invasion.Biomedical optics express · 2024Article
- Polarimetric second-harmonic generation microscopy of partially oriented fibers I: Digital modeling.Biophysical journal · 2023Article
- Corneal imaging with blue-light optical coherence microscopy.Biomedical optics express · 2022Article
- PSHG-TISS: A collection of polarization-resolved second harmonic generation microscopy images of fixed tissues.Scientific data · 2022Article
- Adverse events after riboflavin/UV-A corneal cross-linking: a literature review.International ophthalmology · 2022Review
- Quantitative structural imaging of keratoconic corneas using polarization-resolved SHG microscopy.Biomedical optics express · 2021Article
- The effect of intraocular pressure elevation and related ocular biometry changes on corneal OCT speckle distribution in porcine eyes.PloS one · 2021Article
- Green fluorescent protein emission obscures metabolic fluorescent lifetime imaging of NAD(P)H.Biomedical optics express · 2019Article
- Identifying crossing collagen fibers in human corneal tissues using pSHG images.Biomedical optics express · 2019Article
- Comparison of Different Polarization Sensitive Second Harmonic Generation Imaging Techniques.Methods and protocols · 2019Article
- Quantitative Discrimination of Healthy and Diseased Corneas With Second Harmonic Generation Microscopy.Translational vision science & technology · 2019Article
- Morpho-mechanics of human collagen superstructures revealed by all-optical correlative micro-spectroscopies.Communications biology · 2019Article
- Quantitative Analysis of the Corneal Collagen Distribution afterBioMed research international · 2019Article
- Beyond the H&E: Advanced Technologies for in situ Tissue Biomarker Imaging.ILAR journal · 2018Article
- Quantization of collagen organization in the stroma with a new order coefficient.Biomedical optics express · 2018Article
- Multimodal imaging quality control of epithelia regenerated with cultured human donor corneal limbal epithelial stem cells.Scientific reports · 2017Article
- Two-photon optical microscopy imaging of endothelial keratoplasty grafts.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diseases that affect the cornea can lead to severe vision loss and have tremendous social impact. These diseases are associated to deviations from normal structural order and orientation of collagen fibril bundles. Unfortunately, resolving non-invasively the corneal collagen structure is not possible to date. In this work, polarization sensitive second harmonic generation (pSHG) microscopy is used to obtain information with molecular specificity on microstructure of human corneas. This information is used to develop a set of label-free imaging biomarkers that were generated by means of a novel methodology based on mathematical tensorial calculus. The method is proven to be highly sensitive and robust. The use of these biomarkers permits accurate characterization of the anisotropic, depth-dependent, structural organization of corneal collagen fibril bundles without any a priori information. The method can be valuable to improve understanding of microstructural pathophysiological changes of the human cornea close to in vivo conditions.
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