ArticleInternational journal of clinical and experimental medicine2015
Effect of gene polymorphism of COMT and OPRM1 on the preoperative pain sensitivity in patients with cancer.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 22 citations in OpenAlex.
- Role of OPRM1, clinical and anthropometric variants in neonatal pain reduction.Scientific reports · 2020Trial
- Translational genomic research: the role of genetic polymorphisms in MBSR program among breast cancer survivors (MBSR[BC]).Translational behavioral medicine · 2019Trial
- De novo post-COVID-19 chronic pain: a piece of information about risk factor and clinical features.Pain reports · 2025Article
- Association of COMT rs4680 Genotype With Chronic Neuropathic Pain Experience in Patients With Sickle Cell Disease.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2025Article
- The Orphan Receptor GPR151: Discovery, Expression, and Emerging Biological Significance.ACS chemical neuroscience · 2025Review
- Correlation between gene polymorphisms and perioperative analgesia in patients undergoing gynecological surgery.Frontiers in genetics · 2025Article
- Article
- Polymorphisms inGenes · 2022Article
- Genetic Variants Associated with Cancer Pain and Response to Opioid Analgesics: Implications for Precision Pain Management.Seminars in oncology nursing · 2019Review
- Opioid receptor mu 1 (OPRM1) A118G polymorphism (rs1799971) and postoperative nausea and vomiting.American journal of translational research · 2018Article
- Complex Role of Hypnotizability in the Cognitive Control of Pain.Frontiers in psychology · 2018Article
- OPRM1 and COMT Gene-Gene Interaction Is Associated With Postoperative Pain and Opioid Consumption After Orthopedic Trauma.Biological research for nursing · 2017Article
- The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea.Scientific reports · 2017Article
- Association of single nucleotide polymorphisms of ABCB1, OPRM1 and COMT with pain perception in cancer patients.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2015Article
- Genetic associations of perinatal pain and depression.Molecular painArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the effect of COMT and OPRM1 gene polymorphisms on the preoperative pain sensitivity in tumor patients.
methods300 cases of cancer patients undergoing elective surgery were included, and the Val158 Met loci of COMT gene and OPRM1 loci of A118 G gene were genotyped by PCR-RFLP. Pain threshold and pain tolerance threshold were measured using electrical stimulation to investigate the preoperative pain sensitivity in patients with different genotypes.
resultsFor the COMT gene, the pain threshold and pain tolerance threshold of patients with M allele both decreased (both P < 0.001); for PPRM1 gene, pain threshold and pain tolerance threshold of patients with G allele decreased (both P < 0.001). We also found that there was an interaction between the two genes.
conclusionGene polymorphisms of COMT and OPRM1 were correlated with the preoperative pain sensitivity of cancer patients. The patients with M allele of COMT and G allele of OPRM1 had higher preoperative pain sensitivity.
Indexed as
Identifiers
26309696PMC4538055W1203446802What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.