Effect of edaravone on serum SP-A and arterial blood gas in patients with lobectomy.

Li Song, Feng Xiong, Xue-Juan Zhang, Wei-Yi Liu, Yang Zhao, Wei Feng

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Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors at 2 institutions in 1 country.

Li SongDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.

Feng XiongDepartment of Neurosurgery, Rizhao People's Hospital Rizhao, China.

Xue-Juan ZhangDepartment of Medicine, The Affiliated Hospital of Qingdao University Qingdao 266000, China.

Wei-Yi LiuDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.

Yang ZhaoDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.

Wei FengDepartment of Anesthesiology, The Affiliated Hospital of Qingdao University Qingdao 266000, China.

Qingdao University · CNPeople’s Hospital of Rizhao · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo discuss the effect of edaravone on serum pulmonary surfactant protein A (SP-A) and arterial blood gas (ABG) in patients with thoracoscopic lobectomy.

methods40 lung cancer patients with right side of lobectomy were randomly divided into control group (group C, 20 cases) and edaravone group (group E, 20 cases). Group E was treated edaravone (1 mg/kg) between induction and skin incision, dropping within 30 min; group C was treated with equivalent normal saline. The venous and arterial blood were collected in both groups immediately before incision (T0), after 1 h of one-lung ventilation 1 h (T1) and in 1 h after lungs ventilation (T2) for ABG analysis and measurement of serum SP-A level. Results After OLV, serum SP-A levels were significantly increased in both groups (P < 0.05); compared with group C, serum levels of SP-A were reduced (P < 0.05) and ABG was significantly improved in group E.

conclusionEdaravone can reduce serum SP-A levels in patients with lobectomy and alleviate acute lung injury to a certain extent in surgery.

Indexed as

ABG analysisedaravonelung ventilationSP-A

Identifiers

PMID26309693

PMCPMC4538190

OpenAlexW1161049237

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.